Examining the Indirect Effects of Anxiety on A1c via Automatic Negative Thinking and Diabetes-specific Distress in Adolescents with Type 1 Diabetes

6 days 2 hours ago

This study examined the indirect effects of anxiety on A1c via automatic negative thinking and diabetes distress among adolescents with type 1 diabetes (T1D) during the follow-up interval of a randomized controlled trial of an intervention targeting resilience promotion/depression prevention.
Anthony T. Vesco, Kelsey R. Howard, Lindsay M. Anderson, Jaclyn L. Papadakis, Korey K. Hood, Jill Weissberg-Benchell

Validation Study and Outcomes of the Diabetes Quality of Life in Youth Instrument in Haitian Youth with Type 1 Diabetes Residing in Haiti.

1 week 2 days ago

Health-related quality of life (HRQL) in type 1 diabetes is a critical health outcome but has not been studied in many low-income countries. We evaluated the validity of two HRQL instruments, measured HRQL and explored the association between HRQL and glycemic control in youth with diabetes residing in Haiti.
Ysnel Victor, Viviane Lorgeat, Bidjinie Coriolan, Zahra Kamal, Rosemarie Vincent, Julia E. von Oettingen, Ketly Altenor

The Acceptability of Self-Management Group Education to Reduce Fear of Hypoglycaemia as a Barrier to Physical Activity in People Living with Type 1 Diabetes: A Mixed Methods Approach.

2 weeks ago

Mixed methods were used to evaluate a group self-management education intervention to address type 1 diabetes (T1D)-specific barriers to physical activity (PA). We evaluated the acceptability of study resources and procedures.
Marian C. Brennan, Janie A. Brown, Gavin D. Leslie, Nikos Ntoumanis

Suggested Canadian Standards for Perioperative/Periprocedure Glycemic Management in Patients with Type 1 and Type 2 Diabetes

2 weeks ago

Objective: The goal of this quality initiative was to develop consensus standards for glycemic management of patients with diabetes who undergo surgical procedures in Canada.
Ilana Halperin, Janine Malcolm, Sarah Moore, Robyn L. Houlden, of the Canadian Standards for Perioperative/Periprocedure Glycemic Management Expert Consensus Panel

Motivational Stage at CGM Initiation in Pediatric Type 1 Diabetes is Associated with Current Glycemic Control but does not Predict Future CGM Adherence or Glycemic Control

3 weeks 4 days ago

The CGM TIME Trial is a multicentre RCT in children with type 1 diabetes comparing simultaneous pump and CGM to CGM initiation 6 months later (Paradigm™ Veo™, Enlite™ sensor, Medtronic Canada). This study examined SOCRATES’ ability to classify children and parents into distinct motivational stages and the stages’ association with HbA1c at trial entry and outcomes 6 months after CGM initiation.
Kate C. Verbeeten, Jason Chan, Nadia Sourial, Jennilea M. Courtney, Brenda J. Bradley, Karen McAssey, Cheril Clarson, Susan Kirsch, Jacqueline R. Curtis, Farid H. Mahmud, Tammy Cooper, Christine Richardson, Margaret L. Lawson, CGM TIME Trial Study Group…

The Association between Parental Type 1 and Type 2 Diabetes Diagnosis and Major Osteoporotic Fracture Risk in Adult Offspring: A Population-based Cohort Study

3 weeks 4 days ago

Previous research suggests intergenerational influence of diabetes on bone health. We examined the association between parental diabetes and major osteoporotic fracture (MOF) risk in offspring.
Amani F. Hamad, Lin Yan, William D. Leslie, Suzanne N. Morin, Randy Walld, Leslie L. Roos, Shuman Yang, Lisa M. Lix

The effectiveness of workplace interventions to reduce the risk for type 2 diabetes: A systematic review and meta-analysis.

3 weeks 5 days ago

Workplace type 2 diabetes (T2DM) prevention programs vary in intervention, delivery, and methodological approaches. Using predetermined criteria, we evaluated the effect and implementation of workplace interventions to prevent T2DM.
Donna Fitzpatrick-Lewis, Muhammed Usman Ali, Samantha Horvath, Seema Nagpal, Samantha Ghanem, Diana Sherifali

Cardiovascular comorbidity associated with albuminuria in youth onset type 2 diabetes: analyses from the iCARE study

1 month ago

Little is known about the relationship between albuminuria in youth with type 2 diabetes (T2D) and cardiovascular risk. We aimed to determine if youth with T2D and albuminuria have evidence of increased cardiovascular risk and/or earlycardiovascular dysfunction compared to youth with T2D without albuminuria.
Elizabeth A.C. Sellers, Allison B. Dart, Jonathan McGavock, Brandy A. Wicklow

A multi-intervention campaign lowers pediatric and young adult diabetic ketoacidosis hospitalizations in a Canadian province

1 month ago

The Newfoundland and Labrador Diabetic Ketoacidosis Project (NLdkaP) is a multi-intervention, province-wide project aimed at lowering rates of diabetic ketoacidosis (DKA) within the pediatric and young adult populations.
Georgia Darmonkow, Roger Chafe, Rana Aslanova, Donna Hagerty, Laurie Twells, Ola Jill Barter, Leigh Anne Allwood Newhook

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

1 month 1 week ago

Type 1 diabetes is characterized by the autoimmune destruction of insulin secreting β cells. Genetic variations upstream at the insulin (INS) locus contribute to ∼10% of type 1 diabetes heritable risk. Multiple studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear. To date, no large-scale studies have looked at the effect of genetic variation at rs3842753 on INS mRNA at the single cell level. We aligned all human islet single cell RNA sequencing datasets available to us in 2020 to the reference genome GRCh38.98 and genotyped rs3842753, integrating 2315 β cells and 1223 beta-like cells from 13 A/A protected donors, 23 A/C heterozygous donors, and 35 C/C at-risk donors, including adults without diabetes and with type 2 diabetes.
Su Wang, Stephane Flibotte, Joan Camunas-Soler, Patrick E. MacDonald, James D. Johnson

Equity in Health Services Research—Finding Our Way Back

1 month 2 weeks ago

Over the past decade, many Health Services Research (HSR) studies have been guided by the Triple Aim Framework, which was introduced by the Institute for Healthcare Improvement ( in 2007, and includes 3 dimensions: “improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care” (1). The Triple Aim has proven a useful framework for quality improvement and health systems research. This issue of the Canadian Journal of Diabetes features several articles that relate to one or more of the 3 aims: changing Alberta’s insulin pump therapy eligibility criteria to improve selection and safety of individuals living with diabetes (2); using sensor-based technology to improve glycemia in individuals with type 1 diabetes (3); switching primary care providers from fee-for-service to capitation-based remuneration to improve diabetes care (4); and combining SGLT2 inhibitors with GLP-1 receptor agonists to improve cardiorenal outcomes (5), among others.
David J.T. Campbell