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A New Clinical Utility For Tubular Markers To Identify Kidney Responders To Saxagliptin Treatment In Patients With Diabetic Nephropathy


1 day 10 hours ago

Saxagliptin exhibited kidney protective potential through lowering albuminuria in recent clinical studies. We aimed to investigate whether these kidney effects of saxagliptin were mediated by changes in markers of kidney tubular damage; urinary neutrophil gelatinase-associated protein (uNGAL) and liver-fatty acid-binding protein (uL-FABP).
Marwa Mohsen, Ahmed A. Elberry, Raghda RS. Hussein, Alaa Mohamed Rabea, Doaa Mahmoud Khalil, Mohamed EA. Abdelrahim

In This Issue—A Highlight on the Use of Diabetes Registries


2 days 10 hours ago

In this issue Warncke et al (1) report the long-term outcomes of a rare, autosomal form of diabetes—thiamine-responsive megaloblastic anemia-related diabetes (TRMA). The authors aimed to characterize the clinical presentation and outcomes of this disorder and they hypothesized that early thiamine supplementation would result in improved glycemic control. Case reports had previously identified the potential for improving diabetes outcomes with early thiamine supplementation, requiring confirmation or refutation in a larger sample.
Elizabeth A.C. Sellers

Physical Activity Participation in People with an Active Diabetic Foot Ulceration: A Scoping Review


3 weeks 3 days ago

Being physically active on a regular basis has a favorable impact on diabetes-related complications. To the exception of evidence advising individuals with an active diabetic foot ulceration (DFU) to avoid weight-bearing activity, no physical activity (PA) recommendations are currently provided for this population.
Magali Brousseau-Foley, Virginie Blanchette, François Trudeau, Julie Houle

Economic Evaluation of Sucrose Octasulfate Dressing for the Treatment of Diabetic Foot Ulcers for Type 2 Diabetes Patients


3 weeks 5 days ago

Diabetes patients with non-infected neuroischemic diabetic foot ulcers (DFU) treated with sucrose octasulfate (SOS) dressing have been shown to have improved healing compared to patients wearing a similar type of dressing without SOS. This study aimed to estimate the cost-effectiveness of SOS dressing compared to conventional dressings from a Canadian public payer’s perspective.
Jiabi Wen, Xuejing Jin, Fatima Al Sayah, Jeffrey A. Johnson, Mike Paulden, Arto Ohinmaa

Mental Health Matters: Limited Support Remains a Barrier to Optimal Care for Youth With Diabetes


1 month ago

Over 20 years ago, the International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines stated that “psychosocial factors are the most important influences affecting the care and management of diabetes” (1). However, mental health disorders continue to be undiagnosed and access to mental health services remains limited for children (ages <15 years), and youth (ages 15 to 24 years) with diabetes and their families. Children and youth with diabetes have consistently been demonstrated to have higher rates of depression, anxiety, psychological distress and eating disorders compared with their peers without diabetes (2,3).
Meranda Nakhla, Rayzel Shulman, Linda Dimeglio

Implementation of the CANRISK Tool: A Qualitative Exploration Among Allied Health Professionals in Canada


1 month ago

Launched in 2011 by the Public Health Agency of Canada, the Canadian Diabetes Risk Questionnaire (CANRISK) is a self-assessment tool validated in a Canadian sample, but its uptake has never been assessed. We sought to determine the level of current use of the CANRISK tool, identify common facilitators and barriers to its use and recommend future improvements.
Madeleine Bird, Stephanie Cerutti, Ying Jiang, Sebastian A. Srugo, Margaret de Groh

Associations Between Erythrocyte Membrane Fatty Acid Compositions and Biomarkers of Vascular Health in Adults With Type 1 Diabetes With and Without Insulin Resistance: A Cross-Sectional Analysis


1 month 1 week ago

The aim of this study was to assess the relationship between specific erythrocyte fatty acid levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).
Lauren L. O’Mahoney, Rachel Churm, Antonios Stavropoulos-Kalinoglou, Ramzi A. Ajjan, Nicolas M. Orsi, Georgia Mappa, Oliver J. Price, Matthew D. Campbell

SGLT-2 Inhibitors Use in Renal Transplant Patients with Diabetes: A Brief Review of the Current Literature.


1 month 2 weeks ago

Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are a novel class of oral hypoglycemic agents commonly prescribed in type-2 diabetes mellitus (T2DM). They have been shown to slow the progression of diabetic nephropathy and to improve cardiovascular outcomes in high-risk individuals, although major cardiovascular and renal outcome clinical trials have excluded renal transplant patients. The aim of this review was to determine the outcomes and the safety of the use of SGLT2 inhibitors in renal transplant patients with diabetes.
Shirley Shuster, Zeyana Al-Hadhrami, Sarah Moore, Sara Awad, M. Khaled Shamseddin

Impact of the 2016 Canadian Lipid Guidelines on Daily Practice at a Community Hospital


1 month 3 weeks ago

The aim of this study was to determine the impact of the 2016 Canadian cardiovascular society guidelines for the management of dyslipidemia. More specifically, we assessed the use of 1) alternate lipid targets when triglyceride (TG) levels are high; and 2) nonfasting lipid testing.
Louis-Jacques Cartier, Alex Robin, Simon St-Cœur, Mathieu Lagacé, Donaldo D. Canales, Pierre Douville

Parental transmission plays the major role in the high aggregation of type 2 Diabetes in Iranian families: Tehran Lipid and Glucose Study (TLGS)


2 months ago

This research is the first study that aims to evaluate familial aggregation, heritability, and inheritance mode of type 2 diabetes (T2D) in Tehran Lipid Glucose Study (TLGS) participants as a representative sample for the Iranian population.
Mahdi Akbarzadeh, Parisa Riahi, Azra Ramezankhani, Saeid Rasekhi Dehkordi, Mahmoud Amiri Roudbar, Maryam Zarkesh, Kamran Guity, Davood Khalili, Asiyeh Sadat Zahedi, Fereidoun Azizi, Maryam S. Daneshpour