Saxagliptin exhibited kidney protective potential through lowering albuminuria in recent clinical studies. We aimed to investigate whether these kidney effects of saxagliptin were mediated by changes in markers of kidney tubular damage; urinary neutrophil gelatinase-associated protein (uNGAL) and liver-fatty acid-binding protein (uL-FABP).
In this issue Warncke et al (1) report the long-term outcomes of a rare, autosomal form of diabetes—thiamine-responsive megaloblastic anemia-related diabetes (TRMA). The authors aimed to characterize the clinical presentation and outcomes of this disorder and they hypothesized that early thiamine supplementation would result in improved glycemic control. Case reports had previously identified the potential for improving diabetes outcomes with early thiamine supplementation, requiring confirmation or refutation in a larger sample.
Being physically active on a regular basis has a favorable impact on diabetes-related complications. To the exception of evidence advising individuals with an active diabetic foot ulceration (DFU) to avoid weight-bearing activity, no physical activity (PA) recommendations are currently provided for this population.
Diabetes patients with non-infected neuroischemic diabetic foot ulcers (DFU) treated with sucrose octasulfate (SOS) dressing have been shown to have improved healing compared to patients wearing a similar type of dressing without SOS. This study aimed to estimate the cost-effectiveness of SOS dressing compared to conventional dressings from a Canadian public payer’s perspective.
Over 20 years ago, the International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guidelines stated that “psychosocial factors are the most important influences affecting the care and management of diabetes” (1). However, mental health disorders continue to be undiagnosed and access to mental health services remains limited for children (ages <15 years), and youth (ages 15 to 24 years) with diabetes and their families. Children and youth with diabetes have consistently been demonstrated to have higher rates of depression, anxiety, psychological distress and eating disorders compared with their peers without diabetes (2,3).
Launched in 2011 by the Public Health Agency of Canada, the Canadian Diabetes Risk Questionnaire (CANRISK) is a self-assessment tool validated in a Canadian sample, but its uptake has never been assessed. We sought to determine the level of current use of the CANRISK tool, identify common facilitators and barriers to its use and recommend future improvements.
The aim of this study was to assess the relationship between specific erythrocyte fatty acid levels and vascular health in type 1 diabetes (T1D) with and without insulin resistance (IR).
Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are a novel class of oral hypoglycemic agents commonly prescribed in type-2 diabetes mellitus (T2DM). They have been shown to slow the progression of diabetic nephropathy and to improve cardiovascular outcomes in high-risk individuals, although major cardiovascular and renal outcome clinical trials have excluded renal transplant patients. The aim of this review was to determine the outcomes and the safety of the use of SGLT2 inhibitors in renal transplant patients with diabetes.
The aim of this study was to determine the impact of the 2016 Canadian cardiovascular society guidelines for the management of dyslipidemia. More specifically, we assessed the use of 1) alternate lipid targets when triglyceride (TG) levels are high; and 2) nonfasting lipid testing.
Our aim in this study was to characterize clinical associations between peripheral blood immune populations and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus.
This research is the first study that aims to evaluate familial aggregation, heritability, and inheritance mode of type 2 diabetes (T2D) in Tehran Lipid Glucose Study (TLGS) participants as a representative sample for the Iranian population.