Skipping meals is an increasingly common practice to lose weight among North American adults. However, the long-term effect of this practice on incident type 2 diabetes mellitus (T2DM) remains unknown. We assessed whether skipping meals to lose weight is associated with T2DM risk and whether this association is modified by cardiometabolic risk factors.
Diabetes mellitus (DM) is a risk factor for cancer in many organs and associated with an increased risk of cholangiocarcinoma (CCA). The molecular linkage between these diseases has been demonstrated by preclinical studies, which highlight the role of hyperinsulinemia and hyperglycemia in the carcinogenesis and progression of CCA. Recent studies on the emerging role of anti-diabetic medication in the development and progression of CCA show a subclass of anti-diabetic drug has a therapeutic effect on CCA.
The glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-dependent glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinically significant benefits on glycated hemoglobin (A1C), weight, blood pressure and cardiorenal outcomes. The emerging evidence from clinical trials and meta-analyses that have evaluated the combination of these two classes of drugs has been promising. An expert forum that included individuals with expertise in endocrine, cardiology and nephrology issues was held in May 2020 to review the literature on the metabolic and cardiorenal benefits of these two classes, independently and in combination, in adults with type 2 diabetes mellitus.
In individuals with type 1 diabetes (T1D) changes in blood glucose (BG) during high intensity interval exercise (HIE) are smaller than those observed during aerobic exercise. Study outcomes, however, have been variable: some observed significant BG decreases, while others measured BG increases. This study compared BG outcomes between fasting (AME) and post-prandial (PME) HIE in T1D to test the hypothesis that AME would produce a BG increase, while PME would cause BG to decline.
The objectives were to evaluate demographic data, healing rate, recurrence rate, amputation rate and death rate of patients with diabetic foot ulcers (DFUs) treated in a Quebec outpatient diabetic foot ulcer multidisciplinary clinic. Also, another objective was to determine factors associated with higher ulcer recurrence.
In the mid- to late-2000s, many family physicians switched from Family Health Group (FHG) (a blended fee-for-service model) to Family Health Organization (FHO) (a blended capitation model) in Ontario, Canada. The evidence on the link between physician remuneration schemes and quality of diabetes care is mixed in the literature. We examined whether physicians who switched from the FHG to FHO model provided better care for individuals living with diabetes relative to those who remained in the FHG model.
The objectives were to: 1) examine recent strategies and component interventions used to overcome therapeutic inertia in type 2 diabetes mellitus (T2DM), 2) map strategies to the causes of therapeutic inertia they target, and 3) identify causes of therapeutic inertia in T2DM that have not been targeted by recent strategies.A systematic search of literature published from January 2014 to December 2019 was conducted to identify strategies targeting therapeutic inertia in T2DM and key strategy characteristics were extracted and summarized.
Engagement in regular physical activity (PA) is a cornerstone prevention strategy for individuals at risk of developing type 2 diabetes. Interventions targeting PA often fail to result in long-term behaviour changes. Small Steps for Big Changes is a 3-week diabetes prevention program that promotes PA behaviour change in individuals with prediabetes through motivational interviewing-informed counselling. This study aimed to: (a) profile patterns of women’s perceived PA journey over 1-year and (b) understand strategies used to engage in and maintain PA.
Insulin pump therapy, subsidized through the NSIPP, led to improved quality of life, which was experienced differently depending on stage of life.
To investigate the association of blood glucagon levels measured using a double-antibody sandwich enzyme-linked immunosorbent assay with indices of obesity, glycemic control, and renal function in patients with type 2 diabetes mellitus (T2DM).
Obesity has a significant impact on population health and healthcare. Administrative databases might be a useful tool to study obesity at a population level. We aimed to examine the validity of hospital codes for obesity in Ontario, Canada.
Fibrosis and inflammation in the heart of patients with diabetes mellitus alongside increased production of free radicals and collagen are known as diabetic cardiomyopathy. Ginger rhizome has anti-diabetic, antioxidant, and anti-inflammatory effects. Therefore we investigated the effect of ginger extract on diabetes-induced cardiomyopathy in streptozotocin-induced diabetic rats.
The CRASH cross-sectional study was conducted to better understand the severe hypoglycaemia experiences of persons with diabetes (PWD) and caregivers (CGs).
Yucatan, located in the southern region of Mexico is the State in the country with the highest prevalence of uncontrolled diabetes. Because of particular cultural and socioeconomic characteristics, this region faces challenges in health care. The objective of the study was to evaluate the effect of peer support added to a diabetes education program on glycemic control and diabetes related quality of life in comparison to a conventional diabetes education program in patients with type 2 diabetes in a Mexican Mayan community.
The study examined the prevalence and clinical characteristics of SGLT-2 inhibitor associated DKA.
Hypoglycemia is the most common acute complication of type 1 diabetes (T1D) and the potential short- and long-term sequelae can cause children and parents to develop significant fear of hypoglycemia (FOH). FOH and associated anxiety can be disruptive to activities of daily living and lead to reduced quality of life. We sought to determine the extent of FOH among parents of children with T1D within our clinic and to identify factors associated with greater FOH.
Insulin pump therapy is a valuable but costly approach with public funding in Alberta for eligible individuals since 2013. The Provincial Insulin Pump Therapy (IPT) Program Clinical Advisory Committee (CAC) revised and updated the clinical criteria, integrating current literature, best practice and feedback from clinicians.