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Thiamine-responsive megaloblastic anemia related diabetes: long-term clinical outcomes in 23 patients from DPV and SWEET registries


2 days 3 hours ago

To describe clinical presentation and longterm outcomes in a large cohort of children diagnosed with thiamine-responsive megaloblastic anemia (TRMA) related diabetes.
Katharina Warncke, Nicole Prinz, Violeta Iotova, Desiree Dunstheimer, Nicolin Datz, Beate Karges, Mallikarjun V. Jali, Dorothea Linsenmeyer, Birthe Susanne Olsen, Monika Seiwald, Priya Prahalad, Gideon de Sousa, Danièle Pacaud, SWEET and DPV study groups

The Effect of Empagliflozin and Liraglutide on the NLRP3 Inflammasome in a rodent model of type 2 Diabetes Mellitus


4 days 3 hours ago

Chronic inflammation has been identified as an important driver of cardiovascular disease in type 2 diabetes and can lead to higher risk of cardiovascular events and rehospitalization. SGLT2i and GLP1RA represent two classes of drugs which have proven efficacy in the treatment of T2DM to reduce macrovascular complications, however, the exact mechanism behind their cardioprotective properties remain incompletely understood. The NLRP3 inflammasome is implicated in the progression of cardiovascular disease and linked to the progression of cardiovascular risk factors, such as T2DM.
Mark Gordon, Patrick Meagher, Kim A. Connelly

Effect of fish oil on insulin sensitivity in children: A systematic review and meta-analysis of randomized controlled trials


4 days 3 hours ago

Fish oil has been shown to reduce the risk of metabolic disorders. However, the effects of fish oil intervention on glucose metabolism and insulin sensitivity are still controversial, especially in children. The current meta-analysis aimed to evaluate the effects of fish oil intervention on insulin sensitivity in children.
Miao Hou, Wanping Zhou, Ling Sun, Bo Wang, Jie Shen, Lei Cao, Haitao Lv

Feasibility of a 26-week exercise program to improve brain health in older adults at-risk for type 2 diabetes: A pilot study


1 week 5 days ago

Older adults at-risk for type 2 diabetes (i.e., overweight individuals or those with prediabetes) experience accelerated cognitive and brain deficits. Aerobic training is known to improve these deficits, but the effects of resistance training are relatively unknown. Before conducting a large-scale randomized controlled trial to assess the effects of resistance training, we first conducted a pilot feasibility study to examine recruitment, attendance, and retention rates in this population.
Joyla A. Furlano, Lindsay S. Nagamatsu

Restructuring Clinical Trials in Type 1 Diabetes and Exercise in the Context of Patient-Oriented Research: An Intervention Co-Development Protocol


2 weeks 2 days ago

This intervention co-development project targets four primary objectives in the type 1 diabetes (T1D) and exercise context: (1) establishing a network of scientists and patient partners dedicated to research; (2) determining preferences for exercise intervention attributes; (3) identifying core patient-relevant outcomes; and (4) co-developing clinical studies to shape exercise guidelines.
Nika Klaprat, Chantal Benjamin Joel Brandt, Natasha Gregoire, Kennedy Merrill, Dylan Mackay, Jane Yardley, Jonathan McGavock, Canadian Diabetes and Exercise Network (CaDEN) research team

Psychobiology of Appetite and Food Reward in Type 1 and Type 2 Diabetes: Is there a Role for Exercise?


3 weeks 1 day ago

Hyperglycaemia is the defining feature of type 1 (T1D) and type 2 (T2D) diabetes and results from deficient insulin production, impaired insulin-stimulated glucose uptake, or both. It is now well established that hyperglycaemia results in profound metabolic complications, but the effect of diabetes and its associated metabolic effects on homeostatic and hedonic appetite control has received less attention. Inappropriate food choices and excess food intake may promote weight gain, further exacerbating the metabolic consequences of T1D and T2D.
Mark Hopkins, Kristine Beaulieu, Graham Finlayson

Accumulating physical activity in short or brief bouts for glycemic control in people with prediabetes and diabetes


4 weeks ago

Clinical practice guidelines on physical activity and diabetes currently stipulate physical activity can be accumulated in bouts of ≥10 min to meet recommendations for health benefits. Individuals are also encouraged to interrupt prolonged sitting with brief activity breaks, ∼1-5 min in duration. Growing research highlights accumulating activity in shorter bouts across the day as a potential strategy to improve glycemic control and help those that are largely sedentary meet physical activity guidelines.
Courtney R. Chang, Brooke M. Russell, Paddy C. Dempsey, Hannah E. Christie, Matthew D. Campbell, Monique E. Francois

Variability of Clinical Practice Management of Diabetes during Surgery across Canada


4 weeks 1 day ago

As part of a larger project to develop quality standards in perioperative diabetes management, the goal of this project was to assess self-reported management of surgical patients with diabetes across healthcare institutions and specialties in Canada.
Janine Malcolm, Ilana Halperin, Sarah Moore, Robyn L. Houlden, Canadian Standards for Perioperative/Periprocedure Glycemic Management Expert Consensus Panel

Diabetic retinopathy: important biochemical alterations and the main treatment strategies


1 month ago

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by impaired glucose homeostasis, insulin resistance and hyperglycemia. Among its serious multi-systemic complications is diabetic retinopathy (DR), which develops slowly and often insidiously. This disorder, the most common cause of vision loss in working-age adults, is characterized by functional and morphological changes in the retina. It results from the exacerbation of ischemic and inflammatory conditions prompted by alterations in the blood vessels, such as the development of leukostasis, thickening of the basement membrane, retinal neovascularization and fibrovascular tissue formation at the vitreoretinal interface.
A.S. Valdez-Guerrero, J.C. Quintana-Pérez, M.G. Arellano-Mendoza, F.J. Castañeda-Ibarra, F. Tamay-Cach, D. Alemán-González-Duhart

Assessing the Quality of Evidence Presented at the Annual Conferences of Diabetes Canada


1 month 1 week ago

Annual general meetings (AGMs) are often seen and promoted as great sources of contemporary information for the modern healthcare professional. The quality of research evidence presented at these conferences, however, remains unclear. This paper evaluates the level of evidence (LoE) of research presented at the 2015 to 2019 AGMs of Diabetes Canada (DC).
Muhammad Shoker, Logan Hahn, Ameen Patel, Nasim Zamir

HbA1c and Blood Pressure Levels in Type 2 Diabetes: How Many Patients are on Target?


1 month 1 week ago

Achieving HbA1c and blood pressure targets is an important strategy for preventing chronic vascular complications in diabetes. The aim of this paper was to determine the proportion of type 2 diabetes patients who meet the recommended HbA1c and arterial blood pressure targets and the determinants of failure to do so.
C.B. Farias, S. Coelli, F. Satler, L. Brondani, T. Zelmanovitz, S.P. Silveiro