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Prospective study of skipping meals to lose weight as a predictor of incident type 2 diabetes with potential modification by cardiometabolic risk factors: the Canadian 1995 Nova Scotia Health Survey


4 days 16 hours ago

Skipping meals is an increasingly common practice to lose weight among North American adults. However, the long-term effect of this practice on incident type 2 diabetes mellitus (T2DM) remains unknown. We assessed whether skipping meals to lose weight is associated with T2DM risk and whether this association is modified by cardiometabolic risk factors.
Allie S. Carew, Rania A. Mekary, Susan Kirkland, Olga Theou, Ferhan Siddiqi, Robin Urquhart, Chris Blanchard, Ratika Parkash, Mark Bennett, Kerry L. Ivey, Kenneth Mukamal, Frank Hu, Eric B. Rimm, Leah E. Cahill

Association of Diabetes Mellitus and Cholangiocarcinoma: Update of Evidence and The Effects of Anti-diabetic Medication


4 days 16 hours ago

Diabetes mellitus (DM) is a risk factor for cancer in many organs and associated with an increased risk of cholangiocarcinoma (CCA). The molecular linkage between these diseases has been demonstrated by preclinical studies, which highlight the role of hyperinsulinemia and hyperglycemia in the carcinogenesis and progression of CCA. Recent studies on the emerging role of anti-diabetic medication in the development and progression of CCA show a subclass of anti-diabetic drug has a therapeutic effect on CCA.
Charupong Saengboonmee, Wunchana Seubwai, Worachart Lert-itthiporn, Thanachai Sanlung, Sopit Wongkham

Practical Considerations and Rationale for GLP-1 Receptor Agonist Plus SGLT2 Inhibitor Combination Therapy in Type 2 Diabetes


6 days 16 hours ago

The glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-dependent glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinically significant benefits on glycated hemoglobin (A1C), weight, blood pressure and cardiorenal outcomes. The emerging evidence from clinical trials and meta-analyses that have evaluated the combination of these two classes of drugs has been promising. An expert forum that included individuals with expertise in endocrine, cardiology and nephrology issues was held in May 2020 to review the literature on the metabolic and cardiorenal benefits of these two classes, independently and in combination, in adults with type 2 diabetes mellitus.
Ronald M. Goldenberg, Vineeta Ahooja, Kristin K. Clemens, Jeremy D. Gilbert, Megha Poddar, Subodh Verma

Fasting May Alter Blood Glucose Responses to High Intensity Interval Exercise in Adults with Type 1 Diabetes: A Randomized Acute Crossover Study


1 week ago

In individuals with type 1 diabetes (T1D) changes in blood glucose (BG) during high intensity interval exercise (HIE) are smaller than those observed during aerobic exercise. Study outcomes, however, have been variable: some observed significant BG decreases, while others measured BG increases. This study compared BG outcomes between fasting (AME) and post-prandial (PME) HIE in T1D to test the hypothesis that AME would produce a BG increase, while PME would cause BG to decline.
Jane E. Yardley

Outcomes of Diabetic Foot Ulcers in a tertiary referral interdisciplinary clinic; a retrospective Canadian study


1 week 1 day ago

The objectives were to evaluate demographic data, healing rate, recurrence rate, amputation rate and death rate of patients with diabetic foot ulcers (DFUs) treated in a Quebec outpatient diabetic foot ulcer multidisciplinary clinic. Also, another objective was to determine factors associated with higher ulcer recurrence.
Fournier Cynthia, Singbo Narcisse, Morissette Nadesh, Thibeault Marie-Marthe

Quality of diabetes care in blended fee-for-service and blended capitation payment systems


1 week 6 days ago

In the mid- to late-2000s, many family physicians switched from Family Health Group (FHG) (a blended fee-for-service model) to Family Health Organization (FHO) (a blended capitation model) in Ontario, Canada. The evidence on the link between physician remuneration schemes and quality of diabetes care is mixed in the literature. We examined whether physicians who switched from the FHG to FHO model provided better care for individuals living with diabetes relative to those who remained in the FHG model.
Mary Aderayo Bamimore, Rose Anne Devlin, Gregory S. Zaric, Amit X. Garg, Sisira Sarma

Strategies to overcome therapeutic inertia in type 2 diabetes mellitus: A scoping review


1 week 6 days ago

The objectives were to: 1) examine recent strategies and component interventions used to overcome therapeutic inertia in type 2 diabetes mellitus (T2DM), 2) map strategies to the causes of therapeutic inertia they target, and 3) identify causes of therapeutic inertia in T2DM that have not been targeted by recent strategies.A systematic search of literature published from January 2014 to December 2019 was conducted to identify strategies targeting therapeutic inertia in T2DM and key strategy characteristics were extracted and summarized.
Paulina K. Wrzal, Andrean Bunko, Varun Myageri, Atif Kukaswadia, Calum S. Neish, Noah M. Ivers

“It’s a life thing, not a few months thing”: Profiling Patterns of the Physical Activity Change Process and Associated Strategies of Women with Prediabetes Over 1-Year


1 week 6 days ago

Engagement in regular physical activity (PA) is a cornerstone prevention strategy for individuals at risk of developing type 2 diabetes. Interventions targeting PA often fail to result in long-term behaviour changes. Small Steps for Big Changes is a 3-week diabetes prevention program that promotes PA behaviour change in individuals with prediabetes through motivational interviewing-informed counselling. This study aimed to: (a) profile patterns of women’s perceived PA journey over 1-year and (b) understand strategies used to engage in and maintain PA.
Corliss Bean, Tineke Dineen, Mary E. Jung

Ginger (Zingiber Officinale Roscoe) Extract Protects Heart against Inflammation and Fibrosis in Diabetic Rats


2 weeks 4 days ago

Fibrosis and inflammation in the heart of patients with diabetes mellitus alongside increased production of free radicals and collagen are known as diabetic cardiomyopathy. Ginger rhizome has anti-diabetic, antioxidant, and anti-inflammatory effects. Therefore we investigated the effect of ginger extract on diabetes-induced cardiomyopathy in streptozotocin-induced diabetic rats.
Tara Abdi, Maryam Mahmoudabady, Hadi Zare Marzouni, Saeed Niazmand, Majid Khazaei

Peer Support added to Diabetes Education Improves Metabolic Control and Quality of Life in Mayan Adults Living with Type 2 Diabetes: A Randomized Controlled Trial


2 weeks 4 days ago

Yucatan, located in the southern region of Mexico is the State in the country with the highest prevalence of uncontrolled diabetes. Because of particular cultural and socioeconomic characteristics, this region faces challenges in health care. The objective of the study was to evaluate the effect of peer support added to a diabetes education program on glycemic control and diabetes related quality of life in comparison to a conventional diabetes education program in patients with type 2 diabetes in a Mexican Mayan community.
Castillo-Hernandez Karen G., Laviada-Molina Hugo, Hernandez-Escalante Victor M., Molina-Segui Fernanda, Mena-Macossay Leticia, Caballero Augusto E

When low blood sugars cause high anxiety: Fear of hypoglycemia among parents of youth with type 1 diabetes mellitus


1 month ago

Hypoglycemia is the most common acute complication of type 1 diabetes (T1D) and the potential short- and long-term sequelae can cause children and parents to develop significant fear of hypoglycemia (FOH). FOH and associated anxiety can be disruptive to activities of daily living and lead to reduced quality of life. We sought to determine the extent of FOH among parents of children with T1D within our clinic and to identify factors associated with greater FOH.
Leah Abitbol, Mark R. Palmert

Revision of Alberta’s Provincial Insulin Pump Therapy Criteria for Adults and Children with Type 1 Diabetes: Process, Rationale, and Framework for Evaluation


1 month ago

Insulin pump therapy is a valuable but costly approach with public funding in Alberta for eligible individuals since 2013. The Provincial Insulin Pump Therapy (IPT) Program Clinical Advisory Committee (CAC) revised and updated the clinical criteria, integrating current literature, best practice and feedback from clinicians.
Dalal Haddadi, Elizabeth Rosolowsky, Danièle Pacaud, Julie McKeen, Kim Young, Bev Madrick, Lorelei Domaschuk, Peter Sargious, Sue Conroy, Peter A. Senior, Alberta Provincial Insulin Pump Therapy Program Clinical Advisory Committee