This study examined the indirect effects of anxiety on A1c via automatic negative thinking and diabetes distress among adolescents with type 1 diabetes (T1D) during the follow-up interval of a randomized controlled trial of an intervention targeting resilience promotion/depression prevention.
The purpose of this study was to explore the experiences of self-management of feet for patients with diabetes from the perspective of the patient, support person, and health care provider.
To describe screening outcomes and sociodemographic characteristics of patients in an urban tele-ophthalmology screening program for diabetic retinopathy (DR).
Health-related quality of life (HRQL) in type 1 diabetes is a critical health outcome but has not been studied in many low-income countries. We evaluated the validity of two HRQL instruments, measured HRQL and explored the association between HRQL and glycemic control in youth with diabetes residing in Haiti.
Mixed methods were used to evaluate a group self-management education intervention to address type 1 diabetes (T1D)-specific barriers to physical activity (PA). We evaluated the acceptability of study resources and procedures.
Objective: The goal of this quality initiative was to develop consensus standards for glycemic management of patients with diabetes who undergo surgical procedures in Canada.
The magnitude and precision regarding the risk of diabetic ketoacidosis (DKA) with sodium-glucose cotransporter-2 (SGLT2) inhibitors is unclear.
The CGM TIME Trial is a multicentre RCT in children with type 1 diabetes comparing simultaneous pump and CGM to CGM initiation 6 months later (Paradigm™ Veo™, Enlite™ sensor, Medtronic Canada). This study examined SOCRATES’ ability to classify children and parents into distinct motivational stages and the stages’ association with HbA1c at trial entry and outcomes 6 months after CGM initiation.
Previous research suggests intergenerational influence of diabetes on bone health. We examined the association between parental diabetes and major osteoporotic fracture (MOF) risk in offspring.
Workplace type 2 diabetes (T2DM) prevention programs vary in intervention, delivery, and methodological approaches. Using predetermined criteria, we evaluated the effect and implementation of workplace interventions to prevent T2DM.
Little is known about the relationship between albuminuria in youth with type 2 diabetes (T2D) and cardiovascular risk. We aimed to determine if youth with T2D and albuminuria have evidence of increased cardiovascular risk and/or earlycardiovascular dysfunction compared to youth with T2D without albuminuria.
The Newfoundland and Labrador Diabetic Ketoacidosis Project (NLdkaP) is a multi-intervention, province-wide project aimed at lowering rates of diabetic ketoacidosis (DKA) within the pediatric and young adult populations.
Type 1 diabetes is characterized by the autoimmune destruction of insulin secreting β cells. Genetic variations upstream at the insulin (INS) locus contribute to ∼10% of type 1 diabetes heritable risk. Multiple studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear. To date, no large-scale studies have looked at the effect of genetic variation at rs3842753 on INS mRNA at the single cell level. We aligned all human islet single cell RNA sequencing datasets available to us in 2020 to the reference genome GRCh38.98 and genotyped rs3842753, integrating 2315 β cells and 1223 beta-like cells from 13 A/A protected donors, 23 A/C heterozygous donors, and 35 C/C at-risk donors, including adults without diabetes and with type 2 diabetes.
To investigate the association of erythropoietin gene polymorphisms with diabetic retinopathy in type 2 diabetes mellitus patients from north India.
Over the past decade, many Health Services Research (HSR) studies have been guided by the Triple Aim Framework, which was introduced by the Institute for Healthcare Improvement (www.ihi.org) in 2007, and includes 3 dimensions: “improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care” (1). The Triple Aim has proven a useful framework for quality improvement and health systems research. This issue of the Canadian Journal of Diabetes features several articles that relate to one or more of the 3 aims: changing Alberta’s insulin pump therapy eligibility criteria to improve selection and safety of individuals living with diabetes (2); using sensor-based technology to improve glycemia in individuals with type 1 diabetes (3); switching primary care providers from fee-for-service to capitation-based remuneration to improve diabetes care (4); and combining SGLT2 inhibitors with GLP-1 receptor agonists to improve cardiorenal outcomes (5), among others.