1 month ago
Cardiovascular (CV) risk increases in people living with metabolic dysfunction-associated steatohepatitis (MASH). Liver biopsy is the gold standard for diagnosing MASH but impractical on a large scale. However, non-invasive tests, such as Fibrosis-4 score (FIB-4), are useful for staging patients with fibrotic MASH and predict overall, CV, and liver mortality. In the SELECT trial, semaglutide reduced CV risk by 20% versus placebo. This SELECT sub-analysis assessed CV benefits of semaglutide in people at high risk of MASH.
MICHAEL TSOUKAS, SEBASTIAN M. MEYHöFER, BERTRAND CARIOU, CINTIA CERCATO, HELEN M. COLHOUN, ANNE KATRINE DUUN-HENRIKSEN, IRIS KLIERS, A. MICHAEL LINCOFF, ILDIKO LINGVAY, MICHELLE T. LONG, PHILIP NEWSOME, STEPHEN J. NICHOLLS, MARIA DE LOS ANGELES QUIROGA…
1 month ago
The current management of diabetes in our long-term care (LTC) setting does not meet current standards of practice for diabetes management. Continuous glucose monitors (CGM) can detect a hypoglycemic episode when it is happening, allowing for earlier treatment and a reduction in time spent hypoglycemic. Fewer episodes of hypoglycemia and less time spent hypoglycemic have been shown to reduce life-threatening emergencies, reduce the frequency of point-of-care testing (POCT), and inform treatment decisions with respect to insulin dosing.
FIONA THOMPSON-HUTCHISON, IOANA NISTORESCU, CHRIS FAN-LUN, MONA KABANI, SUSAN DEERING, ANITA LONG, ISABELLA ROSSI
1 month ago
Abnormal glucagon levels are a feature of both type 1 and 2 diabetes, but the basic mechanism(s) underlying the control of glucagon secretion from healthy islet α cells are still incompletely understood, despite decades of research. Hormone secretion from α, β, and δ cells are known to be triggered by changes in the cytosolic calcium concentration ([Ca2+]C). Hence, highspeed (6.25 Hz) dynamic [Ca2+]C imaging was performed in Calbryte590AM–loaded α, β, and δ cells within fresh pancreas tissue slices from male and female mice (Glu-Cre:GCaMP6fLoxP) expressing the Ca2+ sensor GCaMP6f preferentially in α cells.
YA-CHI HUANG, MARJAN SLAK RUPNIK, GUY A. RUTTER
1 month ago
Individuals with T1D who experience social disadvantages may have less equitable access to diabetes technologies, contributing to adverse diabetes outcomes. We evaluated associations between social disadvantage indicators and use of insulin pumps and continuous glucose monitors (CGM) in Québec, where CGM are publicly funded; however, insulin pumps are not unless initiated prior to age 18 years.
ALANNA WEISMAN, PARISA KHODABANDEHLOO, PATIENCE FAKEMBE, JOYEUSE SENGA, RAYZEL SHULMAN, LORRAINE L. LIPSCOMBE, HOLLY WITTEMAN, ANANYA BANERJEE, JUSTIN PRESSEAU, MERANDA NAKHLA, MAMAN JOYCE DOGBA, LEIF ERIK LOVBLOM, REMI RABASA-LHORET, ANNE-SOPHIE BRAZEAU
1 month ago
Statins are widely prescribed to lower blood cholesterol and the risk of cardiovascular events. Epidemiological data prompted Health Canada to add warning labels on all statins, indicating an increased risk of higher blood glucose and diabetes (Health Canada, RA-16949). This side effect is important since statin users often share cardiovascular and diabetes risks. Statins inhibit HMG CoA reductase, lowering cholesterol production and increasing hepatic LDL sequestration from the blood. Inhibition of HMG CoA reductase also reduces post-translational protein prenylation1 altering immunity, and providing anti-inflammatory effects independent of cholesterol-lowering.
NAZLI ROBIN, NATHALIE JOUVET, JENNIFER ESTALL, JONATHAN SCHERTZER
1 month ago
In women, obesity has been shown to decrease fertility and the efficacy of fertility treatments. Adopting a healthy lifestyle is recommended for women with obesity seeking fertility treatment to improve their fertility outcomes.
MELISSA FILIPPONE, CHRISTOPHE RICHER DIT LAFLÈCHE, MATEA BELAN, FARRAH JEAN-DENIS, HÉLÈNE LA VOIE, MARIE-HÉLÈNE PESANT, BELINA CARRANZA MAMANE, JEAN-PATRICE BAILLARGEON
1 month ago
The Diabetes Canada/CSEM Professional Conference brings together diabetes care professionals (DCPs), researchers, and stakeholders to share evidence-based treatments, best practices, and emerging priorities. This narrative review examined the work on physical activity and exercise (PAEx) in diabetes care presented at the annual conference between 2012–2022. Abstracts from the conference, published in the Canadian Journal of Diabetes, were reviewed to identify work specific to living with diabetes or diabetes care and examining PAEx-related variables, interventions, or resources.
TRISTAN MURRAY, CHRISTOPHER SHIELDS, KATIE RICHARDS
1 month ago
The inaction of post-graduate medical education to invest in standardization of transgender health training has been recognized as a concern by both physicians and members of the transgender community. Closing this education gap and improving transgender health-care access necessitates the development of consensus-built transgender health objectives of training (THOOT), particularly in endocrinology and metabolism residency programs.
TEHMINA AHMAD, LEIGHTON SCHREYER, CATHERINE YU, RAYMOND FUNG
1 month ago
Exposure to type 2 diabetes (T2D) in utero is associated with long-term risk of chronic kidney disease. The HNF1-α G319S polymorphism increases the risk of developing T2D, however, associations with kidney outcomes prior to diabetes onset is unknown. We sought to evaluate kidney health in children exposed to T2D in utero with and without the HNF1-α G319S polymorphism.
PRISCILLA IRABOR, ALLISON DART, ELIZABETH SELLERS, STEPHANIE GOGUEN, YASH RAWAL, BRANDY WICKLOW
1 month ago
Optimal diet and regular physical activity are key components of type 2 diabetes (T2D) prevention. Small Steps for Big Changes (SSBC) is an evidence-informed and community-based T2D prevention program that empowers individuals to make dietary and exercise behaviour changes. Long-term follow-up is needed to understand the impact of SSBC on these behavioural outcomes.
AZIZE YILDIRIM, JESSICA BOURNE, ALEX COLYER, JOSEPH KELLY, KAELA CRANSTON, NATALIE GRIEVE, MARY E. JUNG
1 month ago
Matricellular protein CCN5/WISP2 is a novel target of IGF-1 and WNT signaling within pancreatic islets. Our previous work suggests that CCN5 promotes β-cell proliferation and survival via Akt/PKB and focal adhesion kinase. To further elucidate the in vivo effects of CCN5, we assessed aP2-CCN5 transgenic mice, which overexpress CCN5 in adipose tissues. These mice exhibit increased serum levels of CCN5, lean body mass, and whole-body energy expenditure.
MARTINA YANG, MAHVASH ZAKIKHANI, VIKTORIA XEGA, JUN-LI LIU
1 month ago
During obesity, nutrient overload disrupts skeletal muscle insulin signaling, leading to insulin resistance and type 2 diabetes. Dysfunctional branched-chain amino acid (BCAA) catabolism increases intracellular branched-chain keto acids (BCKA), which inhibit insulin signaling by activating the mechanistic target of rapamycin (mTOR). Secretion Associated Ras-related GTPase 1b (Sar1b) was recently identified as a BCAA sensor altering mTOR function. Despite high skeletal muscle Sar1b expression, whether Sar1b alters BCAA flux in the muscle to influence insulin action and energy metabolism remains unknown.
MAX MERILOVICH, MAGGIE PICKARD, ANGELLA MERCER, PETRA KIENESBERGER, THOMAS PULINILKUNNIL
1 month ago
Diabetes distress, encompassing the emotional challenges of living with diabetes, is correlated with poorer outcomes. Despite guidelines for addressing distress, research shows that patients are not asked about emotional concerns, and health-care practitioners (HCP) lack confidence in providing psychosocial care. To bridge this gap, our study explored the experiences, needs, and preferences regarding psychosocial care of patients with type 2 diabetes mellitus (T2DM).
CATHERINE YU, YEJIA ZHANG, RACHEL PAN, ETHAN SHAMIS, IRENE LEE
1 month ago
Type 2 diabetes (T2D) remission (A1C < 6.5% without glucose-lowering medications for ≥3 months) is now acknowledged as a management strategy for this condition. Despite the popularity of intermittent fasting (IF), no studies have explored whether IF can promote T2D remission, particularly in real-world settings.
AUDREY PINSONNEAULT-GRENIER, ALEXIS MARCOTTE-CHÉNARD, JONATHAN LITTLE, HASHIM ISLAM
1 month ago
Timely access to specialist endocrine care is limited. An alternative is triaging referrals to advice-only electronic consultations (TReC), where the specialist supports the referring provider for patient management.
GEETHA MUKERJI, HEATHER LOCHNAN, SUSAN HUMPHREY-MURTO, ERIN KEELY
1 month ago
We report a case of renal phosphate wasting secondary to tumour-induced osteomalacia (TIO) originating from a posterior rib tumour. TIO is a rare cause of acquired hypophosphatemia due to paraneoplastic overproduction of fibroblast growth factor-23 (FGF-23).
CLAIRE SONG, SANA GHAZNAVI
1 month ago
The progression of obesity and type 2 diabetes (T2D) is characterized by higher blood glucose, insulin secretion, and insulin resistance. Intermittent fasting (IF), a popular weight loss strategy involving periodic reduction of caloric intake, can improve glycemia. However, IF can decrease muscle mass in people with obesity and/or T2D. Our research aims to characterize lean mass versus fat loss after IF in mice with obesity and features of T2D. High blood insulin levels inhibit lipolysis, hence we hypothesized that obese mice with features of prediabetes would rely more on muscle than fat to maintain energy homeostasis during IF and thus lose more muscle mass.
MEGHAN O. CONN, DANIEL M. MARKO, JONATHAN SCHERTZER
1 month ago
Manitoba has the highest incidence of childhood onset type 2 diabetes (T2D) in Canada. It is our impression that we are seeing increasing numbers of children diagnosed under the age of 10 years.
ELIZABETH SELLERS, BRANDY WICKLOW, LINDSAY SAWATSKY
1 month ago
Type 2 diabetes (T2D) remission is defined as an A1C level <6.5% without using any glucose-lowering medications for at least 3 months. Evidence suggests a >15 kg reduction in body weight through lifestyle changes and/or bariatric surgery is associated with the greatest probability of T2D remission.
TAHMINA RAHMAN, ALEXIS MARCOTTE-CHÉNARD, BARBARA OLIVEIRA, MARGHERITA CAMERANESI, REBECCA MOLLARD, JONATHAN LITTLE, DYLAN MACKAY
1 month ago
Immigrant populations in Canada have a 2 to 3 times greater risk of acquiring type 2 diabetes. Past studies found recent immigrants to Canada were less likely to conduct blood glucose and foot checks, engage in routine physical activity, minimize dietary fat, and seek out health-care experts for diabetes-related information. In addition, they were less likely to benefit from diabetes management programs due to cultural, financial, linguistic, and systemic barriers. We interviewed 5 patients to discuss their experiences with managing diabetes and 10 health-care practitioners to discuss their experiences with immigrant patients.
ANDREA MONIQUE DANAO, SHITAL DESAI
Checked
10 minutes 15 seconds ago
Canadian Journal of Diabetes RSS feed.
Subscribe to Canadian Journal of Diabetes feed
