Canadian Journal of Diabetes

The feasibility and acceptability of physical activity monitoring as an educational tool in the management of paediatric type 1 diabetes


2 months 4 weeks ago

The spontaneous, sporadic and sometimes unpredictable nature of children's physical activity causes fluctuations in blood glucose level and challenges for children with type 1 diabetes. Physical activity monitoring has potential utility. This study aimed to explore the perceptions of physical activity monitoring among healthcare professionals and assess the feasibility and acceptability of using it in the management of paediatric type 1 diabetes.
Helen Quirk, Ben Heller, Neil Wright

Survival of colorectal cancer patients with diabetes mellitus: A meta-analysis


3 months ago

Diabetes mellitus (DM) is associated with an elevated risk of various cancers, among which is colorectal cancer (CRC). Similarly, pre-existing DM may also influence prognosis among patients with CRC. We have performed a systematic review and meta-analysis to assess the association between DM and risk of death and relapse after a diagnosis of CRC.
Fausto Petrelli, Michele Ghidini, Emanuele Rausa, Antonio Ghidini, Mary Cabiddu, Karen Borgonovo, Mara Ghilardi, Maria Chiara Parati, Filippo Pietrantonio, Paolo Sganzerla, Antonio Carlo Bossi

Addressing a Care Gap in Type 1 Diabetes Management: Using the Diabetes Distress Scale in a Community Care Setting to Address Diabetes-Related Treatment Challenges


3 months ago

To bridge the gap between existing clinical evidence and recommendations around screening for diabetes-related distress (DD) and the observation of a low level of adoption of these suggestions in everyday clinical practice. We focused on the use of the Diabetes Distress Scale (DDS) by adult diabetes care specialists.
Zeina Yared, Sarah Blunden, Stephen Stotland

Economic Evaluation of a New Polygenic Risk Score to Predict Nephropathy in Patients with Type-2 Diabetes


3 months ago

The current screening method for diabetic nephropathy (DN) is based upon detection of albumin in the urine and decline of glomerular filtration rate. The latter usually occurs relatively late in the course of the disease. A polygenic risk score (PRS) was recently developed for early prediction of the risk for type 2 diabetes (T2D) patients to develop DN. The aim of this study was to assess the economic impact of the implementation of the PRS for early prediction of DN in T2D patients, compared to usual screening methods, in Canada.
Kimberly Guinan, Catherine Beauchemin, Johanne Tremblay, John Chalmers, Mark Woodward, Muhammad Ramzan Tahir, Pavel Hamet, Jean Lachaine

A Tailored Cognitive-Behavioural Intervention Produces Comparable Reductions in Regimen-Related Distress in Adults With Type 2 Diabetes Regardless of Insulin Use: 12-Month Outcomes From the COMRADE Trial


3 months 1 week ago

Our aim in this study was to determine whether a cognitive-behavioural therapy plus small changes lifestyle intervention can produce comparable improvements in insulin users vs patients not using insulin with uncontrolled type 2 diabetes (T2D) and comorbid depressive or regimen-related distress (RRD) symptoms.
Lesley D. Lutes, Doyle M. Cummings, Kerry Littlewood, Marina T. Le, Kari Kirian, Shivajirao Patil, Chelsey Solar, Marissa Carraway, Bertha Hambidge

A clinical prediction tool identifies patients with diabetes at risk for persistent adverse glycemia in hospital


3 months 1 week ago

Given the high incidence of hyperglycemia and hypoglycemia in hospital and lack of prediction tools for this problem, we developed a clinical tool to assist early identification of individuals at risk for persistent adverse glycemia (AG) in hospital.
Mervyn Kyi, Alexandra Gorelik, Jane Reid, Lois M. Rowan, Paul R. Wraight, Peter G. Colman, Spiros Fourlanos

Simplifying Detection of Copy Number Variations in Maturity Onset Diabetes of the Young


3 months 1 week ago

Copy number variations (CNVs) are large-scale deletions or duplications of DNA that have required specialized detection methods, such as microarray-based genomic hybridization or multiplex ligation probe amplification. However, recent advances in bioinformatics have made it possible to detect CNVs from next generation DNA sequencing (NGS) data. Maturity Onset Diabetes of the Young (MODY) 5 is a subtype of autosomal dominant diabetes that is often caused by heterozygous deletions involving the HNF1B gene on chromosome 17q12.
Amanda J. Berberich, Jian Wang, Henian Cao, Adam D. McIntyre, Tamara Spaic, David B. Miller, Suzanne Stock, Celine Huot, Robert Stein, Joan Knoll, Ping Yang, John F. Robinson, Robert A. Hegele

Glucose control during physical activity and exercise using closed loop technology in type 1 diabetes.


3 months 1 week ago

Guidelines for safe exercise strategies exist for both pediatric and adult patients living with type 1 diabetes. The management of type 1 diabetes during exercise is complex but making insulin dosing adjustments in advance of activity can yield positive outcomes and reduce the likelihood of hypoglycemia. Closed loop (also known as automated insulin delivery) systems are able to partially automate insulin delivery and can assist in exercise and overall management of type 1 diabetes. Current exercise guidelines, however, focus primarily on management strategies for patients using multiple daily injections or open loop insulin pump therapy.
Dessi P. Zaharieva, Laurel H. Messer, Barbora Paldus, David N. O’Neal, David M. Maahs, Michael C. Riddell

“I Had Nobody to Represent Me”: How Perceptions of Diabetes Health-Care Providers’ Age, Gender and Ethnicity Impact Shared Decision-Making in Adults With Type 1 and Type 2 Diabetes


3 months 1 week ago

Our aim in this study was to investigate how patients’ perceptions of their diabetes health-care providers’ (HCP) age, gender and ethnicity impact shared decision-making using the Theory of Planned Behaviour.
Tehmina Ahmad, Shriya Hari, Devin Cleary, Catherine Yu

Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes


3 months 2 weeks ago

Polycystic ovary syndrome (PCOS) is a common reproductive/metabolic condition associated with obesity, type 2 diabetes (T2D) and depression in adult women. Depression in adults is related to PCOS dermatologic manifestations. Adolescents with obesity with or without T2D have elevated depression symptoms, but data from youth with PCOS and obesity with/without T2D are limited.
Jessie Benson, Cameron Severn, Julia Hudnut-Beumler, Stacey L. Simon, Natalie Abramson, Lauren B. Shomaker, Lauren D. Gulley, Anya Taylor, Megan M. Kelsey, Kristen J. Nadeau, Philip S. Zeitler, Laura Pyle, Melanie Cree-Green

Nutrition and Exercise Performance in Adults With Type 1 Diabetes


3 months 2 weeks ago

The best nutritional practices for exercise and sports performance are largely activity specific. The presence of type 1 diabetes undeniably bestows additional factors to consider to manage exercise and ensure adequate nutrients and fuels are available for optimal performance. Whether participating in sports or physical activity on a recreational basis or striving to achieve a high level of athletic performance, individuals with type 1 diabetes must pay attention to their nutritional and dietary patterns, including intake of macronutrients, micronutrients, fluids and supplements, such as caffeine to maintain metabolic and glycemic balance.
Sheri R. Colberg

Does Exercise Timing Affect 24-Hour Glucose Concentrations in Adults With Type 2 Diabetes? A Follow Up to the Exercise-Physical Activity and Diabetes Glucose Monitoring Study


3 months 2 weeks ago

It is well known that exercise can improve the glycemic profile in individuals with type 2 diabetes (T2D). However, the optimal timing of exercise is often debated. Our aim in this study was to compare the effects of exercise performed at different times of the day and different timing in relation to meals on 24-hour glucose profiles in people with T2D.
Matthew Munan, Rebecca A. Dyck, Shaelyn Houlder, Jane E. Yardley, Carla M. Prado, Gary Snydmiller, Normand G. Boulé

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