Canadian Journal of Diabetes

Relationship between plasma growth differentiation factor 15 levels and complications of type 2 diabetes mellitus: a cross-sectional study


2 weeks 2 days ago

To investigate the associations between growth differentiation factor 15 (GDF15) and type 2 diabetes mellitus (T2DM) complications in Chinese community-based population.
Xiaoyan Zhu, Yue Zhang, Fei Liang, Jieyun Yin, Lai Jiang, Wenyan Cai, Jianan Lu, Chen Zhang, Yue Xiao, Haoyue Teng, Wenxin Ge, Yihe Hu, Yan Lu, Jian Su, Jun Zhang, Ming Wu

Behaviour Change To Promote Diabetes Outcomes: Getting More From What We Have Through Dissemination and Scalability


3 weeks 6 days ago

The potential benefits of advanced medical treatments (pharmacotherapies) and technologies (diagnostics, devices, and apps) are unrealized due to lack of sustained behaviour change in individuals living with type 2 diabetes. The lack of scale-up of effective health behaviour change interventions limits health improvement. Identification of mediators of behaviour change (adherence, self-efficacy, intrinsic motivation) can address this limitation by shifting the focus of behaviour change from input (which behaviour change strategy to choose) to output (what can the person adhere to and sustain).
Michael Vallis

Nutritional Recommendations for Type 2 Diabetes: An International Review of 15 Guidelines


4 weeks ago

Recommendations for patients with type 2 diabetes mellitus (T2DM) from clinical practice guidelines (CPGs) may be inconsistent, and little is known about their quality. Our aim in this study was to systematically review the consistency of globally available CPGs containing nutritional recommendations for T2DM and to assess the quality of their methodology and reporting.
Liangying Hou, Long Ge, Qi Wang, Juanjuan He, Tianzhu Qin, Liujiao Cao, Changhao Cao, Diru Liu, Xingrong Liu, Kehu Yang

Assessing Incorporation of Type 1 Diabetes into Identity: Validation of the Accepting Diabetes And Personal Treatment (ADAPT) Survey in Teens and Young Adults


4 weeks 1 day ago

Teens and young adults with type 1 diabetes (T1D) often demonstrate difficulty with diabetes management, as they struggle to navigate the impact of T1D on their identities: their self-concepts, bodies, social networks, life experiences, and desired futures. Positively incorporating T1D into identity may benefit biomedical and psychosocial outcomes. We aimed to validate and assess psychometric properties of the Accepting Diabetes And Personal Treatment (ADAPT) survey, a new measure of incorporation of T1D into one’s identity.
Persis V. Commissariat, Lisa K. Volkening, Stuart A. Weinzimer, Eyal Dassau, Lori M. Laffel

Insulin Reactions: What Do You Do When Your Treatment’s the Trigger?


1 month ago

Up to 2% of patients experience hypersensitivity reactions to their “insulin”; however, less than one third of these reactions are due to the insulin itself; most are due to additives, including those used to delay insulin release (protamine, zinc, meta-cresol) (1,2). Three mechanisms for insulin allergy have been described. Most hypersensitivity reactions to insulin or its additives are type I (immunoglobulin E–mediated); these reactions are immediate reactions that typically manifest as erythema, itching and urticaria, with the possibility of anaphylaxis.
Madeline Edwards, Carmen Liy-Wong, Adam Byrne, Kyle N. Cowan, Alexandra Ahmet

A Comprehensive Therapeutic Patient Education May Improve Wound Healing and Reduce Ulcer Recurrence and Mortality in Persons With Type 2 Diabetes


1 month 1 week ago

The impact of a comprehensive therapeutic patient education (TPE) on the prognosis of diabetic foot ulcer (DFU) has not yet been evaluated in the literature. The purpose of this study was to determine whether TPE is a predictor of outcome in type 2 diabetes patients with DFU.
Adriana Coppola, Tiziana Montalcini, Pietro Gallotti, Anna Ferrulli, Arturo Pujia, Livio Luzi, Carmine Gazzaruso

Patient-reported Benefits and Limitations of Mobile Health Technologies for Diabetes in Pregnancy: A Scoping Review


1 month 2 weeks ago

For women with pre-existing and gestational diabetes, pregnancy involves specialized and intensive medical care to optimize maternal and infant outcomes. Medical management for patients with diabetes in pregnancy typically occurs via frequent face-to-face outpatient appointments. COVID-19–induced barriers to face-to-face care have identified the need for high-quality, patient-centred virtual health-care modalities, such as mobile health (mHealth) technologies. Our aim in this review was to identify the patient-reported benefits and limitations of mHealth technologies among women with diabetes in pregnancy.
Katelyn Sushko, Holly Tschirhart Menezes, Qi Rui Wang, Kara Nerenberg, Donna Fitzpatrick-Lewis, Diana Sherifali

Exploring the Needs of Adults Living With Type 1 or 2 Diabetes Distress Using the Problem Areas in Diabetes 5 Tool


1 month 2 weeks ago

This study investigated the feasibility and acceptability of implementing a screening tool as a part of routine care and the subsequent screening experiences of patients and clinicians. Additionally, potential sources of DD were identified in this clinical population.
Calvin Mach, Jeroselle Bulanadi, Enza Gucciardi, Phillip Segal, Margaret De Melo

Patterns and Patients’ Characteristics Associated With Use of Sodium/Glucose Cotransporter 2 Inhibitors Among Adults With Type 2 Diabetes: A Population-based Cohort Study


1 month 2 weeks ago

Our aim in this study was to describe patterns and patient-level factors associated with use of sodium/glucose cotransporter 2 inhibitors (SGLT2is) among adults with diabetes being treated in Alberta, Canada.
Dennis B. Campbell, David J.T. Campbell, Flora Au, Reed F. Beall, Paul E. Ronksley, Derek S. Chew, Yewande Ogundeji, Braden J. Manns, Brenda R. Hemmelgarn, Marcello Tonelli, Amity E. Quinn

Associations Among Biomarkers of Inflammation, Tubular Injury and Lipid Metabolism With Gestational Diabetes Mellitus Status, Microalbuminuria and Retinopathy in the Microalbuminuria and Retinopathy in Gestational Diabetes Study


1 month 3 weeks ago

Pregnancy may be complicated by gestational diabetes mellitus (GDM) and/or microvascular complications like albuminuria, retinopathy and pre-eclampsia. In this study we aimed to identify whether mechanistic pathways associated with microvascular complications are active in pregnant women with GDM or microvascular disease.
Vikas S. Sridhar, Hongyan Liu, Leif Erik Lovblom, Denice S. Feig, Elaine Herer, Michelle A. Hladunewich, Alexander Kiss, Radha P. Kohly, Lorraine L. Lipscombe, Paul M. Yip, David Z. Cherney, Baiju R. Shah

Can a Mixture of Insulin and a Nonsteroidal Anti-inflammatory Drug Prolong Insulin Pump Catheter Wear Time in Adults With Type 1 Diabetes?


1 month 3 weeks ago

Continuous subcutaneous insulin infusion systems (CSIIs) are commonly used by patients with diabetes. According to manufacturer and health agency recommendations, patients are advised to change their infusion set after 2 to 3 days (1). This rule of thumb is largely based on observational data suggesting that longer wear time is associated with increased catheter malfunctions, adverse events (AEs) at the insertion site and subsequent metabolic complications (2–4). However, in an international survey of 14,015 type 1 or type 2 diabetes CSII users from Europe and North America, over 18% of patients reported wearing their catheters for longer than the recommended time (5).
Jean-Luc Ardilouze, Fernand Gobeil, Ran Cheng, Julie Ménard, Danijela Bovan, Virginie Messier, Martin Savard, Jean-Patrice Baillargeon, Rémi Rabasa-Lhoret

Diabetes of Unclear Type in an Adolescent Boy With Multiple Islet-cell Autoantibody Positivity Successfully Managed With Glucagon-like Peptide-1 Receptor Agonist Alone: A Case Report


1 month 3 weeks ago

Diabetes classification has traditionally considered type 1 and type 2 diabetes as 2 separate entities with different pathogenic mechanisms. However, clinicians and researchers see increasingly more exceptions to this conventional paradigm, leading to a concept of mixed phenotypes in diabetes classification. Herein we report the case of an adolescent with unclear diabetes type due to the presence of obesity, robust endogenous insulin production, multiple islet autoantibody positivity and severe hyperglycemia at diabetes diagnosis that has been successfully treated with liraglutide therapy alone.
Olivia Z.B. Ginnard, Maria J. Redondo, Sarah K. Lyons

Media Portrayal of Chronic Illnesses


1 month 4 weeks ago

In their study, Katz et al explored the depictions of type 1 diabetes (T1D) in North American English-language film and television.1 They highlighted how media often portray patients with T1D negatively, or at times “forget” that characters have T1D. The authors proposed that more advocacy needs to be done by large diabetes organizations. Using Grey’s Anatomy as an example, they emphasized the importance of consulting health professionals to ensure accuracy in media portrayals of patients. As we (a film director, a producer and a physician) have previously collaborated to produce a short film on modifying stigma on people living with chronic illnesses,2,3 we have the following suggestions.
Jamie O.P. Chung, Eddie Kung, Hanson Lu, Benjamin K.P. Woo

Care Endpoints in Adults With Type 2 Diabetes: Screening and Therapeutic Targets at a Canadian Tertiary Diabetes Care Centre


2 months 1 week ago

Although national diabetes guidelines recommend targets for various health parameters, studies have demonstrated a gap between recommendations and real-life practice. The objectives of the present study were to: 1) assess measurements in type 2 diabetes (T2DM) care performed by diabetologists in tertiary care, 2) determine whether these measurements were within recommended targets by Canadian guidelines, and 3) identify how these measurements compare with previously published Canadian studies.
Melissa-Rosina Pasqua, Xiao Wen Hu, Vanessa Tardio, Michael A. Tsoukas

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