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Canadian Journal of Diabetes

Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1

Canadian Journal of Diabetes
4 days 22 hours ago
Obesity and aging are associated with increased activity of the innate immune system. This chronic systemic inflammation contributes to the development of type 2 diabetes and long-term complications and is partly driven by the activation of the NLRP3 inflammasome. We conducted a comparative analysis of clinical parameters, non-esterified fatty acid (NEFA) profiles, immune cell subsets, and inflammatory responses of peripheral blood mononuclear cells obtained from both healthy individuals and those diagnosed with type 2 diabetes.
Joyce de Paula Souza, Justus S. Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S. Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne…

Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study

Canadian Journal of Diabetes
1 week 3 days ago
Patient-centered care is a hallmark of family medicine, and patient-centered care for diabetes has been associated with better outcomes. The Primary Care Diabetes Support Program (PCDSP) in London, Ontario, uses a patient-centered model of care and targets three groups of patients at high risk for diabetes complications: 1) medically complex, 2) socially complex, and 3) those without a primary care provider. We describe, from the patient’s perspectives, how the PCDSP operationalizes patient-centered care.
Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M. Reichert, Lindsay Hedden, Maria Mathews

Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims

Canadian Journal of Diabetes
1 month ago
Ontario listed SGLT-2 inhibitors (SGLT2i) as regular public drug benefits for adults age ≥ 65, while other Canadian provinces providing benefits for SGLT2i implemented special authorization restrictions. We hypothesized that special authorization led to lower SGLT2i use among older adults with diabetes and cardiovascular disease (CVD) in other provinces (Alberta, Manitoba, New Brunswick, and Saskatchewan), compared to Ontario.
Darren Lau, Douglas C. Dover, Hena Qureshi, Roseanne O. Yeung, Dean Eurich, Peter Senior, Sonia Butalia, Padma Kaul

Impact of an Audit and Feedback-based Intervention on Preparation of Adolescents for Transition to Adult Type 1 Diabetes Care: A Multi-Center Quasi-Experimental Study

Canadian Journal of Diabetes
1 month ago
Adolescents and young adults (AYA) often report feeling poorly prepared and dissatisfied with the process of transitioning from pediatric to adult type 1 diabetes (T1D) care. We aimed to examine the impact of Bridging the Gap (BTG), an audit and feedback-based intervention, on transition care.
Syed Zain Ahmad, Noah Ivers, Ian Zenlea, Baiju R. Shah, Peter C. Austin, Cheril Clarson, Jennifer Harrington, Alanna Landry, Geetha Mukerji, Zubin Punthakee, Mark R. Palmert, Janet Parsons, Mikayla Sonnenberg, Rayzel Shulman

The association between insulin regimen and the risk of severe hypoglycemia and mortality in adults with type 2 diabetes. A large population based retrospective cohort study

Canadian Journal of Diabetes
1 month 1 week ago
To compare severe hypoglycemia and all-cause mortality between insulin regimens in people with type 2 diabetes on insulin.
Reid H. Whitlock, Zach Raizman, David Collister, Katherine J. Bernier, Sarah M. Sigurdson, Navdeep Tangri, Clara Bohm, Claudio Rigatto, Paul Komenda, Jennifer M. Yamamoto

Hypertension Treatment and Control in Canadians with Diabetes

Canadian Journal of Diabetes
1 month 2 weeks ago
We investigated hypertension control (<130/80 mmHg) among individuals with diabetes, use of first-line antihypertensive medications, and physician responses to uncontrolled blood pressure (BP) measurements (i.e. repeat measurements and medication intensification).
Sachin V. Pasricha, Lisa Dubrofsky, Bailey Goldman, Laura O’Driscoll, Huijuan Yang, Shane Golden, Brad Millson, Sheldon W. Tobe

“Beyond Glucose Control: A Critical Appraisal of Virtual vs. In-Person Care for Gestational Diabetes”

Canadian Journal of Diabetes
1 month 3 weeks ago
the article by Dolatabadi et al. offers timely insights into the use of virtual care in managing gestational diabetes mellitus (GDM), but several critical limitations temper the strength and applicability of its conclusions. This Letter to the Editor outlines concerns regarding the study’s retrospective design, its omission of patient-reported and adherence-related outcomes, and its limited generalizability. Drawing on recent literature, including evaluations aligned with the Quadruple Aim and meta-analyses of digital interventions, we argue for more robust and patient-centered methodologies in future research.
Muhammad Khubaib Iftikhar

Describing the experiences of healthcare providers who supported an outreach program to deliver point-of-care screening in adults with Type 1 and Type 2 diabetes who are experiencing homelessness in Calgary, Canada: A qualitative analysis.

Canadian Journal of Diabetes
1 month 3 weeks ago
Unstable housing and homelessness are associated with increased risks of diabetes-related morbidity and mortality. Concordantly, as few as 12-30% of people with lived experience of homelessness (PWLEH) complete recommended screening for microvascular complications of diabetes. Innovative models of care delivery are needed to address this disparity. We recently piloted a novel, community-based, point-of-care screening program for diabetes complications (the SAFER model of care, i.e. Screening for glycosylated hemoglobin (A1c), feet, eyes and renal function) in Calgary, Alberta.
Hannah M. Yaphe, Sara Scott, Huanghe Ding, Breanna McSweeney, Eshleen Grewal, David JT. Campbell

Addendum to “Glycemic Management Across the Lifespan for People With Type 1 Diabetes: A Clinical Practice Guideline” [Can J Diabetes. 2025;49:5–18]

Canadian Journal of Diabetes
2 months 2 weeks ago
The publisher regrets that Supplementary Material failed to be published with this article and is now included. The publisher apologizes for any inconvenience caused.
Ilana J. Halperin, Brandy Wicklow, Shazhan Amed, Alanna Chambers, Charlotte Courage, Elizabeth Cummings, Patricia Kirkland, Dylan MacKay, Meranda Nakhla, Zubin Punthakee, Paul M. Ryan, Lindsay Sawatsky, Peter A. Senior, Bikrampal S. Sidhu, Alanna Weisman…
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