2 months 3 weeks ago
Diabetes disproportionately affects Indigenous communities in Canada, with higher prevalence rates and severe complications. Historical trauma, socio-economic disparities, and inappropriate health-care practices compound these challenges. This case study examines the model of care of the Indigenous Diabetes Health Circle (IDHC) and its impact on Indigenous communities in Ontario. After obtaining internal ethical approval, a researcher immersed themselves within the IDHC for 6 months, observing frontline worker-client interactions and videos, and documenting the organization's culturally safe practices, utilizing ethnographic methods.
SAMAH HASSAN, ROSLYNN BAIRD, AUTUMN WATSON, JAMES BOWEN, SUJA MATHEW, VALERIA RAC
2 months 3 weeks ago
Regular physical activity (PA) benefits those with type 1 diabetes (T1D), yet many are below recommended activity levels. This study aimed to assess knowledge and barriers to PA in the T1D population using an online questionnaire.
ALEXANDER ST JOHN, CATRIONA FARRELL, MONEEZA SIDDIQUI, ANNA BARNETT, RORY MCCRIMMON, ALISON MCNEILLY
2 months 3 weeks ago
In Canada, Indigenous (First Nation, Métis, and Inuit) children and youth are experiencing an epidemic of type 2 diabetes (T2D). Given the prevalence of pediatric T2D and its impact on Indigenous youth and their families, effective culture-based interventions are urgently needed to promote improved health outcomes. The purpose of this research project is to co-create culture-based T2D education interventions among youth. In this presentation, we describe the findings outlining the Knowledge Keepers and adult participants’ conceptions of hope with respect to health promotion and T2D prevention which are providing the foundation for co-developing education interventions.
SHELLEY SPURR, JILL BALLY, MERIDITH BURLES, CATHY LANGDON, ALLISON CAMMER
2 months 3 weeks ago
Incretin receptor agonists, including GLP1, are used extensively to treat type 2 diabetes, and restore both insulin secretion and sensitivity. To explore how GLP1 agonism impacts islet β-cell Ca2+ dynamics in vivo, we engrafted islets expressing the calcium indicator GCaMP6f into the anterior eye chamber (ACE) of control, diet- or genetically-induced hyperglycemic mice. Following engraftment (21 weeks-post-surgery), islet Ca2+ was monitored by confocal imaging through the front of the eye in anesthetized animals at days 0, 1, and 7.
LUIS FERNANDO DELGADILLO-SILVA, SHADAI SALAZAR, PRISCILA CARAPETO, SANDRA LAROUCHE, AUDREY PROVENCHER-GIRARD, ALEXANDRE PRAT, GUY A. RUTTER
2 months 3 weeks ago
Diabetic cardiomyopathy (DCM) is a common complication of diabetes that can lead to heart failure. In this study, we investigated mechanisms through which cell death occurs in cultured H9c2 cardiomyoblasts treated with high glucose (25 mM). We examined the cardioprotective effects of the adiponectin receptor agonist, ALY688, and the mechanisms through which the protective effects are exerted, namely attenuation of inflammation and induction of autophagy. Western blot to detect caspase-3 showed a significant increase in cleaved caspase-3 levels following 24-hour treatment under high-glucose conditions compared to normal glucose, indicating activation of apoptosis in H9c2 cells.
SAHER AHMED, CARINA TANG, KHANG NGUYEN, EDDIE TAM, HYE KYOUNG SUNG, ALI ABDUL-SATER, GARY SWEENEY
2 months 3 weeks ago
Obesity-related heart disease is associated with metabolic remodeling and defective organelle function in the cardiomyocyte. Transcription factor EB (TFEB) is the bona fide regulator of lysosomal function. Fatty acid overload depletes TFEB, perturbing lysosomal function. We tested the hypothesis that a decline in cardiomyocyte TFEB during diet-induced obesity (DIO) remodels energy metabolism and triggers cardiac dysfunction. Wild type (TFEBfl/fl -/-) and cardiomyocyte TFEB knockout (TFEBfl/fl Cre/-) mice were fed low-fat (LF;10 kcal% from fat) or high-fat (HF; 60 kcal% from fat) diet for 20 weeks.
GURPREET KAUR, SHANMUGASUNDARAM PAKKIRISWAMI, ADITHI PISAPATI, PURVI TRIVEDI, NEHAL WADNIKOP, ALEX QUINN, WAI NIANG, ANGELLA MERCER, PETRA KIENESBERGER, THOMAS PULINILKUNNIL
2 months 3 weeks ago
Metabolic disorders are associated with changes in the intestinal microbiome which produces metabolites that are substrates for host metabolism. Our group previously showed that D-lactate, the enantiomer of L-lactate, is a key bacterial-derived substrate contributing to liver glycogen and fat. Therefore, we aimed to understand the role of D-lactate in hyperglycemia. We show that D-lactate levels in portal serum are significantly higher in hyperglycemic and normoglycemic obese mice relative to their healthy controls.
DANA KUKJE ZADA, HAN FANG, CLAUDIA GAGNON, ANDRÉ TCHERNOF, ANDRÉ MARETTE, JONATHAN SCHERTZER
2 months 3 weeks ago
We evaluated associations between social disadvantage and insulin pump use among adults with type 1 diabetes (T1D) in the context of a universal publicly-funded insulin pump program, and whether social disparities in insulin pump program enrollment have decreased over time.
YOUSTINA SOLIMAN, ALANNA WEISMAN, KARL EVERETT, RAYZEL SHULMAN, PETER AUSTIN, LORRAINE L. LIPSCOMBE, GILLIAN BOOTH
2 months 3 weeks ago
Device-based physical activity and weight self-monitoring are understudied in gestational diabetes (GDM), despite the importance of health behaviours to maternal and fetal outcomes.
KABERI DASGUPTA, DEBBIE CHAN, RACHEL TALIA BOND, SUSAN JOANNE WANG, NATASHA GARFIELD, JILLIAN COOLEN, ILANA HALPERIN, TRICIA M. PETERS, GARRY X. SHEN, JENNIFER YAMAMOTO, SONIA BUTALIA, JOHN DOWLING, LAURA RENDON, KATE HAICHIN, ARIANE GODBOUT, DEBORAH DA…
2 months 3 weeks ago
Beta cells adapt to metabolic stressors by increasing insulin secretion to prevent diabetes. We have shown that prolactin receptor (Prlr) is required for beta-cell adaptation to insulin resistance of pregnancy. Moreover, when multiparous Prlr-null (βPrlr-/-) female mice were challenged with a high-fat diet (HFD), they became glucose intolerant. Interestingly, while Prlr signaling regulates beta-cell proliferation during pregnancy, Prlr signaling appears to regulate insulin content and incretin receptor expression in response to obesity.
DANIEL LEE, RANEET KAHLON, CAROL HUANG
2 months 3 weeks ago
No randomized, controlled trial has assessed the efficacy and safety of subcutaneous semaglutide in type 1 diabetes.
MELISSA-ROSINA PASQUA, MICHAEL TSOUKAS, ADNAN JAFAR, AHMAD HAIDAR, ALESSANDRA KOBAYATI
2 months 3 weeks ago
In the SELECT trial, in patients with established cardiovascular (CV) disease and BMI ≥27 kg/m2, once weekly (OW) semaglutide 2.4 mg reduced risk of the composite endpoint (CV death, myocardial infarction, and stroke) and the risk of all-cause mortality versus placebo. This analysis investigated semaglutide 2.4 mg effect on all-cause mortality, CV and non-CV death, including subcategories of death and death from COVID-19.
MARIE PHILIPPE MORIN, BENJAMIN M. SCIRICA, HELEN M. COLHOUN, JOHN DEANFIELD, OLE KLEIST JEPPESEN, PETER E. WEEKE, ILDIKO LINGVAY, SøREN ØSTERGAARD HARDT-LINDBERG, DONNA H. RYAN, ANA LAURA DE SOUZA ALMEIDA MATOS, A. MICHAEL LINCOFF
2 months 3 weeks ago
The fatty-acid receptor FFA4 is expressed in islets, but its mechanisms of action remains unknown. Our previous studies suggest that FFA4 regulates somatostatin (SST) secretion from delta cells.
LAURA REININGER, NAOMI CINQUE, CAROLINE TREMBLAY, MELANIE ETHIER, JULIEN GHISLAIN, MARK HUISING, VINCENT POITOUT
2 months 3 weeks ago
T1D can be treated with islet transplantation, but limited donors necessitate new cell sources. hESCβs are an alternative; however, insufficient glucose-regulated excitability, sensing, and insulin release prevent hESCβs from being an alternative for cell-replacement therapy today.
JASMINE MAGHERA, PATRICK MACDONALD, FRANCIS LYNN
2 months 3 weeks ago
In the SELECT cardiovascular outcomes trial, semaglutide reduced major adverse cardiovascular events by 20% among people with established cardiovascular disease and overweight or obesity but without diabetes. In this prespecified analysis, main kidney outcomes were examined in SELECT.
DAVID C.W. LAU, HELEN M. COLHOUN, ILDIKO LINGVAY, PAUL M. BROWN, JOHN DEANFIELD, KIRSTINE BROWN-FRANDSEN, STEVEN E. KAHN, JORGE PLUTZKY, KOICHI NODE, ALEXANDER PARKHOMENKO, LARS RYDÉN, JOHN P.H. WILDING, JOHANNES F.E. MANN, KATHERINE R. TUTTLE, THOMAS…
2 months 3 weeks ago
Advances in genetic testing have allowed for increasingly personalized health care. While many endocrinological conditions are sporadic and impacted by environmental factors, there are several conditions which have strong genetic determinants. This single-centre, retrospective descriptive study aimed to characterize the use and impacts of genetic testing in endocrinology clinical practice. 216 adults and children underwent genetic testing using next generation sequencing (n=183) or Sanger sequencing (n=33).
REBECCA WONG, AMANDA BERBERICH
2 months 3 weeks ago
Despite established weight management approaches in Canada, cost-effectiveness remains unclear for new medications like tirzepatide compared to existing therapies and bariatric surgery. This analysis aims to inform policy makers, practitioners, and patients.
NISHA GUPTA, ALEXANDRA BABYAK, ARENI CHORBAJIAN, JEROMIE BALLREICH, KABERI DASGUPTA
2 months 3 weeks ago
Evidence has shown that decreased renal function is associated with enhanced interstitial fibrosis in patients with diabetic kidney disease (DKD). We have previously published that MKP-2 expression is reduced in the kidney of diabetic mice and patients. Interestingly, only diabetic mice with MKP-2 deletion presented with tubular fibrosis, a hallmark of DKD.
MARINA ROUSSEAU, FARAH LIZOTTE, PEDRO GERALDES
2 months 3 weeks ago
We evaluated the impact of implementing guideline-based lobectomy criteria and ThyroSPEC molecular testing on lobectomy and completion thyroidectomy rates.
CAITLIN YEO, JIAHUI WU, PAUL STEWARDSON, MARKUS ESZLINGER, SANA GHAZNAVI, RALF PASCHKE
2 months 3 weeks ago
This study aimed to quantify the relative importance (RI) of frequency of administration among basal insulin treatment preferences of Canadians living with type 2 diabetes (T2D). People living with T2D completed a discrete choice experiment (DCE) in an online survey. Eleven choice tasks, based on 6 treatment attributes (5 x 3 levels; 1 x 2 levels; 2 treatment profiles per task) were completed. Hierarchical Bayesian estimation was used to calculate part-worth utilities to estimate RI of attributes.
PAM HALLWORTH, GODFREY MAU, SOPHI TATLOCK, BETHANY BELL, LEWIS ORMEROD, SOPHIE WALLACE, ANN BESNER
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1 hour 29 minutes ago
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