Canadian Journal of Diabetes

Toward the Goal of Understanding and Tackling the Social Determinants of Diabetes

2 months 3 weeks ago

Diabetes cannot be understood purely by research into biological and lifestyle factors. Significant social determinants of health (SDOH), such as income, employment and housing, play a critical role yet remain under-studied. Indigenous, racialized, LGBTQ2S+ and low-income communities are disproportionately impacted by diabetes. These inequalities are shaped by the distribution of money, power and resources, and were propelled to the fore during the COVID-19 pandemic. Understanding and mitigating the impact of social determinants of diabetes are urgent priorities given the prevalence and economic cost of the disease.
Suman Prinjha, Brandy Wicklow, Meranda Nakhla, Ananya Tina Banerjee

Sex-dependent Effect of In-utero Exposure to Δ9-Tetrahydrocannabinol on Glucagon and Stathmin-2 in Adult Rat Offspring

2 months 3 weeks ago

Administration of Δ9-tetrahydrocannabinol (Δ9-THC) to pregnant rats results in glucose intolerance, insulin resistance and reduced islet mass in female, but not male, offspring. The effects of Δ9-THC on other islet hormones is not known. One downstream target of the cannabinoid receptor, stathmin-2 (Stmn2), has recently been shown to suppress glucagon secretion, thereby suggesting Δ9-THC may also affect alpha-cell function. The aim of the present study was to determine the effects of in-utero Δ9-THC exposure on the profile of glucagon, insulin and Stmn2 in the rat offspring islet and serum.
Farzad Asadi, Juan Andres Fernandez Andrade, Ryan Gillies, Kendrick Lee, Savita Dhanvantari, Daniel Barry Hardy, Edith Juliana Arany

A Multimodal Intervention for Reducing Unnecessary Repeat Glycated Hemoglobin Testing

3 months ago

Reducing unnecessary tests that do not enhance quality can promote health-care value. Glycated hemoglobin (A1C) is often ordered at a frequency exceeding the recommendation of once every 3 months. We conducted a quality improvement (QI) initiative aimed to reduce unnecessary repeat testing by 75% at a tertiary care academic hospital.
Jason Baek, Vamana Rajeswaran, Susan Tran, Lisa Alexander, Diana Jaskolka, Shirine Usmani, Paul Yip, Geetha Mukerji

Gaps in Referral to Bariatric Surgery for Patients With Type 2 Diabetes Seen in Endocrinology Clinics

3 months 1 week ago

One third of adults in Canada are overweight and 26.8% experience obesity. Bariatric surgery confers effective weight loss and reduces obesity-related complications, including type 2 diabetes, but remains an underutilized treatment. Our objective in this study was to determine whether a gap exists in bariatric program referrals for patients with type 2 diabetes seen in endocrinology clinics at an ambulatory tertiary care hospital in Toronto, Canada.
Sheila Holmes, Shohinee Sarma, Sara Campbell, Abdulrahman Azab, Judy Qiang, Geetha Mukerji

Sodium–glucose cotransporter-2 inhibitor–associated Euglycemic Diabetic Ketoacidosis: Lessons From a Case Series of 4 Patients Undergoing Coronary Artery Bypass Grafting Surgery

3 months 1 week ago

Euglycemic diabetic ketoacidosis (DKA) is a potentially life-threatening adverse condition associated with use of sodium–glucose cotransporter-2 inhibitors (SGLT2i). This risk is further pronounced in the perioperative period. There is no consensus for when SGLT2i should be held preoperatively, and recommendations from various organizations have evolved from 1 day to 3 to 4 days in the latest American Diabetes Association guidelines. Further study of patients with perioperative euglycemic DKA is required to help clarify the optimal timing of preoperative discontinuation of SGLT2i agents.
Ahsen Chaudhry, Craig Roels, Julie Lee

Determinants of Wellness: A Perspective on Diabetes and Indigenous Health

3 months 1 week ago

It is well established that Indigenous populations of all ages experience higher rates of diabetes, particularly type 2 diabetes (T2D) and gestational diabetes (1,2). The social (and sometimes structural) determinants of health (SDOH) provide a framework for describing inequities in health outcomes related to race and ethnicity, income, education, housing, built environments, food security and other factors unique to social contexts. Although SDOH disaggregated by Indigenous status have provided some insight into drivers of health inequity, caution must be exercised when findings are generalized across Indigenous peoples.
Taylor S. Morriseau

Do-it-yourself and Commercial Automated Insulin Delivery Systems in Type 1 Diabetes: An Uncertain Area for Canadian Healthcare Providers

3 months 1 week ago

In the past century, since the discovery of insulin, methods of insulin delivery and glucose monitoring have advanced technologically. In particular, the introduction of insulin pumps, providing continuous subcutaneous insulin infusion (CSII), and continuous glucose monitors (CGM) have been revolutionary for people living with type 1 diabetes. In this review, we have focussed on automated insulin delivery (AID) systems and discuss the implications of both approved and off-label options for the user and healthcare providers.
Amy E. Morrison, Peter A. Senior, Tania Bubela, Kate Farnsworth, Holly O. Witteman, Anna Lam

Functional AGXT2 SNP rs37369 Variant Is a Risk Factor for Diabetes Mellitus: Baseline Data From the Aidai Cohort Study in Japan

3 months 1 week ago

The relationship between alanine-glyoxylate aminotransferase 2 (AGXT2) single-nucleotide polymorphisms (SNPs) and diabetes mellitus (DM) has not been investigated. Therefore, we performed a case–control study to examine this relationship.
Hiroshi Kumon, Yoshihiro Miyake, Yuta Yoshino, Jun-ichi Iga, Keiko Tanaka, Hidenori Senba, Eizen Kimura, Takashi Higaki, Bunzo Matsuura, Ryuichi Kawamoto, Shu-ichi Ueno

Training the Next Generation of Diabetes Researchers: Evaluation of the Diabetes Action Canada Training and Mentoring Program

3 months 2 weeks ago

The Diabetes Action Canada Training and Mentoring (DAC-TM) Program launched in June 2017, with the goal of building capacity in the next generation of diabetes researchers in Canada in patient-oriented research (POR).
Monika Kastner, Julie Makarski, M. Bianca Seaton, Kimia Sedig, Mathieu Bélanger, André C. Carpentier, André Gaudreau, Gloria Lourido, Michelle Murray, Katie N. Dainty

3 hours 52 minutes ago
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