1 month ago
A 22-year-old female diagnosed with X-linked hypophosphatemia (XLH) confirmed on DNA analysis with a pathogenic variant c.1936G>T in the PHEX gene was being treated with conventional therapy consisting of phosphate and active vitamin D. She was intolerant of the phosphate and not compliant with the active vitamin D. She had major physical limitations due to bone pain and generalized weakness. She also had developed depression with suicidal ideation. She was not able to afford burosumab, the monoclonal Ab to FGF23.
PARWANA MUHAMMAD, ALIYA KHAN
1 month ago
Women often report that it is increasingly difficult to maintain a healthy body weight after having children. Excessive gestational weight gain and age at first birth are risk factors for postpartum weight retention. However, whether parity is associated with impaired weight loss has yet to be determined. Here, we examined the association between parity and rate of weight loss and age of obesity onset in 2,219 women who completed a supervised clinical weight loss program. Rate of weight loss was calculated during the first 6 weeks of a 900-kcal meal replacement protocol (Optifast 900).
DHANUDDARA MOHOTTALAGE, CHANTAL PILEGGI, MAJID NIKPAY, TIM RAMSAY, RUTH MCPHERSON, ROBERT DENT, MARY-ELLEN HARPER
1 month ago
Sodium-glucose cotransporter inhibitors (SGLTi) have proven cardiorenal benefits in type 2 diabetes and are promising as adjunct-to-insulin therapy in patients living with type 1 diabetes (T1D). Clinical use in T1D has been limited owing to a lack of regulatory approval and augmented risk of diabetic ketoacidosis (DKA). Patient and physician input is critical in understanding how and when the risk-benefit ratio is perceived to be favorable. This study explored how risks and benefits are considered by patients living with T1D and by the physicians who treat their condition.
DAVID CAMPBELL, PAMELA LEBLANC, CHLOE PAREZANOVIC, DAVID CHERNEY, BRUCE PERKINS, RONALD SIGAL, VIKAS SRIDHAR, ANITA LAYTON, TONY LAM, SEAN BARBOUR, ADEERA LEVIN, LEIF ERIK LOVBLOM, ISTVAN MUCSI, REMI RABASA-LHORET, ALEKSANDRA VUKOBRADOVIC, PETER SENIOR,…
1 month ago
Group Education Trial to Improve Transition in Adolescents with Type 1 Diabetes (GET-IT-T1D) aims to assess whether group education sessions better prepare adolescents with type 1 diabetes (T1D) for transition to adult care. Patient satisfaction is important to evaluate quality of care. We aimed to 1) describe satisfaction with group education sessions, and 2) evaluate predictors of satisfaction.
SIMON LAFONTAINE, OLIVIER RENAUD-CHAREST, ELISE MOK, JENNIFER FREI, MÉLANIE HENDERSON, ELHAM RAHME, KABERI DASGUPTA, MERANDA NAKHLA
1 month ago
The weight loss effects of semaglutide have been studied in many randomized controlled trials. However, real-world data on its use is limited. This study aims to explore the pattern of semaglutide prescription and associated outcomes in an academic family medicine practice.
ARMIN FARAHVASH, RAHUL JAIN, LIISA JAAKKIMAINEN
1 month ago
People living with T1D spend a few hours a year with health-care providers, as diabetes is primarily self-managed. This burden can weigh heavily on the individual, especially for vulnerable populations. The Peer 2 Peer (P2P) mentorship program (by I Challenge Diabetes) was created to support individuals living with T1D in developing critical skills for diabetes self-management. The objective of this study was to evaluate the implementation of P2P from the mentor perspective.
KATHARINE MACKETT, MICHELLE GREENWAY, DIANA SHERIFALI, RUSSELL DE SOUZA, CHRIS JARVIS, JULIA PESEK, NANCY SANTESSO
1 month ago
Dietitians working in primary care (PC) treat patients with foods and nutrition issues. They are important interprofessional team members collaborating with other professionals to provide quality and equitable care to patients, including those with diabetes. However, their full scope of practice is not well known by other professionals, which can hinder collaboration in the team-based care model. The objective was to assess Canadian dietitians’ perception about interprofessional collaboration in PC, which led to the development of asynchronous virtual simulation-based learning modules to strengthen competencies.
ISABELLE GIROUX, WENDY MADARASZ, JANE TYERMAN, JACLYN ADLER, SERENA BEBER, MARY ANNE SMITH, JOIE SHAW, JOSEPH MURPHY, DENIS TSANG, ÉLIANE BOUCHARD, RAPHAËLLE LAROCHE-NANTEL
1 month ago
Adiposopathy is a major contributing factor for type 2 diabetes (T2D) and can result in complications. This study explored the perspectives of people with T2D regarding the value and expected impacts of reaching a lower weight.
MELISSA ROSS, SARAH MULNICK, MEREDITH HOOG, KRISTINA BOYE, CHRISTINE LONGUET, ASHLEY SAMUELSON, VIVIAN THIEU, MICHAEL VALLIS, JENNIFER GLASS
1 month ago
Ten years ago, the “Building Competency in Diabetes Education resource manual: Diabetes Physical Activity and Exercise” (aka “Toolkit”) was introduced to diabetes care professionals (DCPs) across Canada. The launch of this resource resulted in improvements in physical activity and exercise (PAEx)-related perceptions and practices among DCPs; however, what the status of PAE promotion is in diabetes care today is unclear. This national cross-sectional study examined the current PAEx perceptions and practices of DCPs (N=116).
CHRISTOPHER SHIELDS, KATIE RICHARDS, JONATHON FOWLES
1 month ago
Increased plasma low-density lipoprotein conjugated dienes (PLDL-CDs) are associated with elevated inflammation (as measured by plasma C-reactive protein [PCRP]) which exacerbates type 2 diabetes (T2D). The objective was to test the novel hypothesis that PLDL-CDs’ reduction responsiveness to antioxidant-containing flaxseed lignan complex (FLC) consumption relative to placebo would be associated with a PCRP level reduction in older type 2 diabetes patients (OT2DP).
DOUGLAS BARRE
1 month ago
While insulin is the main therapy for cystic fibrosis-related diabetes (CFRD), repaglinide has been an alternative. Elexacaftor-tezacaftor-ivacaftor (ETI), a modulator of the cystic fibrosis transmembrane conductance regulator, is routinely prescribed for those who are eligible. ETI and repaglinide are substrates of common hepatocyte transporters. Each drug may result in increased transaminases, causing liver toxicity. There are limited safety data regarding the use of these medications together.
MIRNA GERGES, MEREDITH CHIASSON, CARLY NICHOLS, NANCY MORRISON, SARAH SUTHERLAND, BARNA DE
1 month ago
Some population-based studies from Japan, Korea, and the US have suggested hearing impairment (HI, or loss of hearing acuity) as an underrecognized microvascular complication of diabetes mellitus (DM). In this study, we aimed to determine the prevalence and odds ratios (ORs) of HI among Canadians with pre-diabetes (pre-DM) and DM using the Canadian Longitudinal Study on Aging comprehensive dataset. In total, 23 749 eligible participants were categorized as either control group, group with pre-DM, or group with DM.
NHI NGUYEN, ADRIAN FUENTE
1 month ago
People living with type 1 diabetes (PwT1D) have a heightened concern of their body image due to weight gain that may be related to insulin administration, frequent bodyweight monitoring, and stigma. As body image dissatisfaction (BID) is associated with an elevated risk of developing an eating disorder, there is a need to accurately predict BID. Objectives: We aimed to 1) compare machine learning (ML) models (Decision Trees, Random Forest, Extreme Gradient Boosting, and K Nearest Neighbours) and evaluate their predictive performance of BID; and 2) identify important predictors.
COURTNEY SOUTH, SHAHRYAR EBRAHIMI, ANNE-SOPHIE BRAZEAU, MARIA CUTUMISU
1 month ago
Obesity is now recognized as a chronic disease. The Edmonton Obesity Staging System (EOSS) was suggested for the prediction of health adverse outcome among individuals with overweight/obesity. Metabolic syndrome, as defined by the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria has been linked to cardiometabolic complications, including type 2 diabetes. We aim to determine the predictive value of EOSS staging and NCEP ATP III criteria for each of all-cause, cardiovascular, and cancer-related mortality occurring before the median age of death for each of men and women in Canada among individuals with obesity enrolled in the Ottawa Hospital Weight Management Program.
BELINDA ELISHA, MAJID NIKPAY, HEATHER LOCHNAN, MARY-ELLEN HARPER, RUTH MCPHERSON, ROBERT DENT
1 month ago
Existing gestational diabetes mellitus (GDM) prevention programs may not adequately address the needs of Indigenous women, especially those living in urban areas where access to health-promoting traditional foods and activities may be limited. To better serve this population, their unique experiences and challenges with pregnancy, GDM, and prenatal health care must be considered.
LESLIE REDMOND, SINA SARVIHA, HALEY GROSS, JOANNA CANDAS
1 month ago
Primary hyperparathyroidism (PHPT), which is associated with nephrocalcinosis and nephrolithiasis, may lead to kidney dysfunction. Current clinical practice guidelines recommend young patients (<50 years) and those with PHPT-related complications, including kidney disease (defined by an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2), be referred for parathyroidectomy. However, the impact of parathyroidectomy on longer term kidney function remains unclear. We aimed to examine the impact of parathyroidectomy on eGFR at 365 days compared to conservative management (e.g., monitoring, calcium/vitamin D supplementation, antiresorptive therapy).
IRIS LIU, DHEEPTHI THOMMANDRAM, AKSHAY VARGHESE, AHMED AL-SHAER, DEMETRI PANANOS, HEATHER LAPIER, STAN VAN UUM, TAYYAB KHAN, JOHN YOO, DANIELLE MACNEIL, KRISTIN CLEMENS
1 month ago
Type 2 diabetes (T2D) is associated with impaired cognition and hemodynamics. These impairments may be due to disrupted brain blood flow and neurovascular coupling. In 26 individuals with T2D and 1 with prediabetes (52% female, age 64±13years, BMI=28±5.1 kg/m2, diabetes duration=14±13years, A1C=7.0±1.5%), resting heart rate (RHR), mean arterial pressure (MAP), and cardiac output index (Qi; normalized to body surface area) were measured with a standard single-lead electrocardiogram and Finometer Pro device.
OLIVIA RAMRAJ, NATASHA ANITA, SI WON RYOO, FELICIA KWAN, WALTER SWARDFAGER, HEATHER EDGELL, SHIROPA NOOR
1 month ago
Beta-cell function and mass are under the control of G protein-coupled receptors (GPCRs) which are themselves subject to intracellular regulation by RGS proteins. Although the importance of GPCRs to beta-cell biology is well documented, the role of RGS proteins is largely unknown. Recent evidence suggests that RGS9 may have a role in the control of insulin secretion. This study was designed to elucidate the role and mechanism of action of RGS9 in the rodent beta cell. qPCR and RNA in situ hybridization were performed on isolated mouse islets and pancreatic sections, respectively.
SARAH FERRAGNE, SCOTT CAMPBELL, LAURA REININGER, CAROLINE TREMBLAY, JULIEN GHISLAIN, VINCENT POITOUT
1 month ago
Cellular senescence has been implicated in age-related tissue dysfunction, including in type 2 diabetes (T2D). Our lab has identified distinct beta-cell subsets, termed "leaders” and "hubs,” with distinct intracellular calcium dynamics and connectivity that are essential for insulin secretion. We hypothesize that senescent beta cells, marked by p21(CDKN1A), may overlap with these functionally-specialized cells.
PRISCILA CARAPETO, GIADA OSTINELLI, LUIS FERNANDO DELGADILLO-SILVA, CRISTINA AGUAYO-MAZZUCATO, GUY A. RUTTER
1 month ago
Objective: The purpose of this systematic review was to identify risk factors to help prevent dementia for adults living with type 2 diabetes, with links to both diseases identified, for screening, optimizing self-management, with broad impact of costs saved. No universal screening method exists for cognitive decline. Self-management of type 2 diabetes with increasing health-care costs of managing both diseases are impacted.
SUZANNE OVENDEN, ANTHONY BREITBACH
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