Canadian Journal of Diabetes

Psychosocial Experiences of Adolescents with Type 2 Diabetes: A Systematic Review and Meta-Synthesis


6 days 7 hours ago

Globally, the prevalence of Type 2 Diabetes (T2D) among adolescents is increasing. While T2D is known to bring physical health challenges, less is known about adolescents’ psychosocial experiences of T2D. We aimed to identify and synthesize existing qualitative research about adolescents’ psychosocial experiences of T2D to inform healthcare recommendations.
Melissa Oxlad, Lorraine Smith, Tyla McNamara, Ashley Young, Ella Borrowdale, Alexia Pena

Patterns in the incidence (1994-2018) and prevalence (2004-2018) of type 1 and type 2 diabetes among Nova Scotian youth under 20 years


2 weeks ago

Rates of type 1(T1D) and type 2(T2D) diabetes in youth may be increasing globally; however, findings vary across populations. We aimed to determine changes in incidence and prevalence of T1D and T2D over a 25-year period (1994-2018) in youth under age 20 in Nova Scotia(NS).
Elizabeth A. Cummings, Teresa Pinto, Maya Rao, Pam Talbot

Identifying Potential Sustainable and Scalable Interventions to Recognize Signs of Diabetes in Children Across Canada


2 weeks 5 days ago

Delayed diagnosis of diabetes in children can lead to diabetic ketoacidosis, a life-threatening condition occurring in 10-80% of children at diabetes diagnosis. Ketoacidosis is preventable with prompt recognition of signs, urgent attendance to care, and rapid diagnosis and management. The objective of this study was to plan for the development of an intervention to recognize signs of diabetes in children and prevent ketoacidosis, that is evidence and theory-informed and has potential for widespread implementation and long-term impact across Canada.
Zeenat Ladak, Priscilla Medeiros, Geneviève Rouleau, Jennifer Shuldiner, Shazhan Amed, Elizabeth Cummings, Manpreet Doulla, Josephine Ho, Mark Inman, Sarah E. Lawrence, Patricia Li, Elizabeth Moreau, Meranda Nakhla, Julia Von Oettingen, Elizabeth Sellers…

Physician-reported pediatric diabetes virtual visit quality and outcome not associated with social determinants of health


1 month 3 weeks ago

Social determinants of health (SDH) impact diabetes outcomes. In response to COVID-19, virtual care ensured healthcare access. However, socially disadvantaged groups have less technology access and skills, leading to potential disparities. We assessed the association between SDH and virtual visit success in children living with diabetes.
Laurence Bastien, Ellen B. Goldboom, Ewa Sucha, Richard J. Webster, Ivan Terekhov, Caroline Zuijdwijk

The assessment of clinical factors influencing Glucose Management Indicator and Hba1c discordance in children with type one diabetes – one-year real-world data observation.


1 month 3 weeks ago

Published data still highlighted discordances between GMI (parameter estimating HbA1c from CGM report) and laboratory HbA1c, with reasons yet to be explored. This study aimed: to identify potential clinical factors contributing to these discordances.
Grażyna Deja, Aleksandra Brudzińska, Łukasz Wybrańczyk, Rafal Deja, Przemysława Jarosz-Chobot.

Can a Combined Epigenetic-Biomarker Score Supplant Chronologic Age as an Independent Determinant of Incident Death in Adults with Dysglycemia


2 months ago

Diabetes and prediabetes are associated with premature death and are recognized as conditions of accelerated biologic aging. To date, the best measurement of biologic age is chronologic age. Measures of biologic age that can replace chronologic age as a predictor of death can better approximate risk in affected individuals.
Hertzel C. Gerstein, Guillaume Pare, Keyun Zhou, Serena Yang, Michael Chong, Gregory R. Steinberg, Shun Fu Lee

A diabetes peer mentorship program for First Nations youth and young adults: An intervention protocol


2 months 1 week ago

The rising incidence of type 2 diabetes (T2D) among Indigenous peoples, exacerbated by historical injustices and health inequities, underscores the need for culturally-sensitive health interventions that address both the physiological and psychological burdens of diabetes. This research protocol describes a community-driven initiative aimed at enhancing diabetes management among Indigenous youth and young adults in Canada, leveraging the lived experience and leadership of Indigenous young adults.
Sahar Fazeli, Jonathan Linton, Paul Linton, Lucy Trapper, Catherine Godin, Helene Porada, Deborah Da Costa, Kaberi Dasgupta, Isabelle Malhame, Claudia Mitchell, Elham Rahme, Julia Elisabeth Von Oettingen, Romina Pace

Multidisciplinary Lifestyle Intervention in a Clinical Setting Leads to Remission of Type 2 Diabetes, Prediabetes, and Early Insulin Resistance


2 months 2 weeks ago

Trials using intensive lifestyle interventions have demonstrated remission of type 2 diabetes mellitus (T2DM), but data on real-world clinical approaches remain limited.
Christopher Gudas-Cantin, Valérie Dionne, Élise Latour, Karine Lamoureux, Lyne Chevrefils, Chantal Gariepy, Marie-Hélène Morissette C, Lina Mokdad, Juliette Morin, Sarah-Maude Martin, Mathieu Gayda, Florent Besnier, Sara Desmarais, Anil Nigam, Philippe L…

In The Eye Of Controversy: A Deeper Look Into The Impact Of Glucagon-Like Peptide 1 Receptor Agonists (GLP1RA) on Diabetic Retinopathy and Non-arteritic anterior ischemic optic neuropathy (NAION)


2 months 2 weeks ago

Glucagon-like peptide 1 receptor agonists (GLP1RA), a relatively new class of drugs, are widely used in treating type 2 diabetes mellitus and obesity. Maintaining long-term glycemic control lowers the risk of development and progression of diabetic retinopathy. However, recent literature has raised concerns about transient worsening of the condition with GLP1RA use.
Nadia Nadeem, Raghad Mazin Al Issa, Asnin Shah, Rahaf Wardeh, Fauzia Rashid, Elamin Ibrahim Abdelgadir, Alaaeldin Bashier

Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1


2 months 4 weeks ago

Obesity and aging are associated with increased activity of the innate immune system. This chronic systemic inflammation contributes to the development of type 2 diabetes and long-term complications and is partly driven by the activation of the NLRP3 inflammasome. We conducted a comparative analysis of clinical parameters, non-esterified fatty acid (NEFA) profiles, immune cell subsets, and inflammatory responses of peripheral blood mononuclear cells obtained from both healthy individuals and those diagnosed with type 2 diabetes.
Joyce de Paula Souza, Justus S. Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S. Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne…

Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study


3 months ago

Patient-centered care is a hallmark of family medicine, and patient-centered care for diabetes has been associated with better outcomes. The Primary Care Diabetes Support Program (PCDSP) in London, Ontario, uses a patient-centered model of care and targets three groups of patients at high risk for diabetes complications: 1) medically complex, 2) socially complex, and 3) those without a primary care provider. We describe, from the patient’s perspectives, how the PCDSP operationalizes patient-centered care.
Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M. Reichert, Lindsay Hedden, Maria Mathews

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