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Canadian Journal of Diabetes

A diabetes peer mentorship program for First Nations youth and young adults: An intervention protocol

Canadian Journal of Diabetes
3 days ago
The rising incidence of type 2 diabetes (T2D) among Indigenous peoples, exacerbated by historical injustices and health inequities, underscores the need for culturally-sensitive health interventions that address both the physiological and psychological burdens of diabetes. This research protocol describes a community-driven initiative aimed at enhancing diabetes management among Indigenous youth and young adults in Canada, leveraging the lived experience and leadership of Indigenous young adults.
Sahar Fazeli, Jonathan Linton, Paul Linton, Lucy Trapper, Catherine Godin, Helene Porada, Deborah Da Costa, Kaberi Dasgupta, Isabelle Malhame, Claudia Mitchell, Elham Rahme, Julia Elisabeth Von Oettingen, Romina Pace

Multidisciplinary Lifestyle Intervention in a Clinical Setting Leads to Remission of Type 2 Diabetes, Prediabetes, and Early Insulin Resistance

Canadian Journal of Diabetes
6 days ago
Trials using intensive lifestyle interventions have demonstrated remission of type 2 diabetes mellitus (T2DM), but data on real-world clinical approaches remain limited.
Christopher Gudas-Cantin, Valérie Dionne, Élise Latour, Karine Lamoureux, Lyne Chevrefils, Chantal Gariepy, Marie-Hélène Morissette C, Lina Mokdad, Juliette Morin, Sarah-Maude Martin, Mathieu Gayda, Florent Besnier, Sara Desmarais, Anil Nigam, Philippe L…

In The Eye Of Controversy: A Deeper Look Into The Impact Of Glucagon-Like Peptide 1 Receptor Agonists (GLP1RA) on Diabetic Retinopathy and Non-arteritic anterior ischemic optic neuropathy (NAION)

Canadian Journal of Diabetes
1 week 2 days ago
Glucagon-like peptide 1 receptor agonists (GLP1RA), a relatively new class of drugs, are widely used in treating type 2 diabetes mellitus and obesity. Maintaining long-term glycemic control lowers the risk of development and progression of diabetic retinopathy. However, recent literature has raised concerns about transient worsening of the condition with GLP1RA use.
Nadia Nadeem, Raghad Mazin Al Issa, Asnin Shah, Rahaf Wardeh, Fauzia Rashid, Elamin Ibrahim Abdelgadir, Alaaeldin Bashier

Blood characteristics of patients with type 2 diabetes and response of their peripheral blood mononuclear cells to inhibitors of the NLRP3-inflammasome and caspase-1

Canadian Journal of Diabetes
3 weeks ago
Obesity and aging are associated with increased activity of the innate immune system. This chronic systemic inflammation contributes to the development of type 2 diabetes and long-term complications and is partly driven by the activation of the NLRP3 inflammasome. We conducted a comparative analysis of clinical parameters, non-esterified fatty acid (NEFA) profiles, immune cell subsets, and inflammatory responses of peripheral blood mononuclear cells obtained from both healthy individuals and those diagnosed with type 2 diabetes.
Joyce de Paula Souza, Justus S. Fischer, Karine Jeanneau, Cyril Allard, Eline Angevaare, Dominik Aschenbrenner, Ursula Bodendorf, Benjamin Demarco, John S. Gounarides, Saskia Killmer, Jiri Kovarik, Sabina Pfister, Hong Yin, Vithushan Ratnarasa, Marianne…

Patient perspectives of the operationalization of adult patient-centered care at the Primary Care Diabetes Support Program, London, Ontario: A Qualitative Descriptive Study

Canadian Journal of Diabetes
3 weeks 6 days ago
Patient-centered care is a hallmark of family medicine, and patient-centered care for diabetes has been associated with better outcomes. The Primary Care Diabetes Support Program (PCDSP) in London, Ontario, uses a patient-centered model of care and targets three groups of patients at high risk for diabetes complications: 1) medically complex, 2) socially complex, and 3) those without a primary care provider. We describe, from the patient’s perspectives, how the PCDSP operationalizes patient-centered care.
Gillian Young, Anika Garg, Dana Ryan, Leslie Meredith, Stewart Harris, Sonja M. Reichert, Lindsay Hedden, Maria Mathews

Do Provincial Formulary Restrictions Explain Differential Uptake of Sodium-Glucose Co-Transporter-2 Inhibitors in Adults with Diabetes and Cardiovascular Disease in Canada? A Retrospective Cohort Study of Pharmacy Claims

Canadian Journal of Diabetes
1 month 3 weeks ago
Ontario listed SGLT-2 inhibitors (SGLT2i) as regular public drug benefits for adults age ≥ 65, while other Canadian provinces providing benefits for SGLT2i implemented special authorization restrictions. We hypothesized that special authorization led to lower SGLT2i use among older adults with diabetes and cardiovascular disease (CVD) in other provinces (Alberta, Manitoba, New Brunswick, and Saskatchewan), compared to Ontario.
Darren Lau, Douglas C. Dover, Hena Qureshi, Roseanne O. Yeung, Dean Eurich, Peter Senior, Sonia Butalia, Padma Kaul

Impact of an Audit and Feedback-based Intervention on Preparation of Adolescents for Transition to Adult Type 1 Diabetes Care: A Multi-Center Quasi-Experimental Study

Canadian Journal of Diabetes
1 month 3 weeks ago
Adolescents and young adults (AYA) often report feeling poorly prepared and dissatisfied with the process of transitioning from pediatric to adult type 1 diabetes (T1D) care. We aimed to examine the impact of Bridging the Gap (BTG), an audit and feedback-based intervention, on transition care.
Syed Zain Ahmad, Noah Ivers, Ian Zenlea, Baiju R. Shah, Peter C. Austin, Cheril Clarson, Jennifer Harrington, Alanna Landry, Geetha Mukerji, Zubin Punthakee, Mark R. Palmert, Janet Parsons, Mikayla Sonnenberg, Rayzel Shulman

The association between insulin regimen and the risk of severe hypoglycemia and mortality in adults with type 2 diabetes. A large population based retrospective cohort study

Canadian Journal of Diabetes
1 month 4 weeks ago
To compare severe hypoglycemia and all-cause mortality between insulin regimens in people with type 2 diabetes on insulin.
Reid H. Whitlock, Zach Raizman, David Collister, Katherine J. Bernier, Sarah M. Sigurdson, Navdeep Tangri, Clara Bohm, Claudio Rigatto, Paul Komenda, Jennifer M. Yamamoto

Hypertension Treatment and Control in Canadians with Diabetes

Canadian Journal of Diabetes
2 months ago
We investigated hypertension control (<130/80 mmHg) among individuals with diabetes, use of first-line antihypertensive medications, and physician responses to uncontrolled blood pressure (BP) measurements (i.e. repeat measurements and medication intensification).
Sachin V. Pasricha, Lisa Dubrofsky, Bailey Goldman, Laura O’Driscoll, Huijuan Yang, Shane Golden, Brad Millson, Sheldon W. Tobe
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