Canadian Journal of Diabetes
The Diabetes Canada Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada (CPG) were last published in 2018 (1). Rapid uptake of new monitoring technologies by persons living with diabetes and uncertainty among health-care professionals prompted a review of evidence emerging since our previous recommendations for “Monitoring Glycemic Control” (2). We have updated the title for this topic to align with Diabetes Canada’s position statement on “Language Matters” (3).
Does the presence of type 2 diabetes or metabolic syndrome impact reduction in waist circumference during weight loss?
To compare the change in waist circumference given the same degree of weight loss in patients who meet the criteria for metabolic syndrome or type 2 diabetes and those who do not. Since visceral adiposity, is a key feature of both conditions, we hypothesized that patients with metabolic syndrome or diabetes lose a greater amount of waist circumference given the same amount of weight loss compared to patients without these conditions.
Foregone opportunities? Time-to-treatment intensification among adults with type 2 diabetes and elevated HbA1c on metformin monotherapy, 2009-2018
We characterized time-to-treatment intensification (TTI) in people on metformin with uncontrolled hyperglycemia, and estimated the frequency of physician visits until intensification.
Approaches to psychosocial care within tertiary care diabetes centres in Canada: An environmental scan.
Patients with diabetes facing psychosocial challenges often struggle with diabetes self-management, and thereby are at risk of complications arising from hyperglycemia. Despite the Diabetes Canada Clinical Practice Guidelines’ recommendations for diabetes centres to offer psychosocial services for the screening and support of patients with psychosocial barriers, the extent to which these recommendations have been implemented in centres across Canada is unknown.
Real-world incidence and risk factors for daytime and nocturnal non-severe hypoglycemia in adults with type 2 diabetes mellitus on insulin and/or secretagogues (InHypo-DM Study, Canada)
To estimate the real-world incidence of self-reported non-severe hypoglycemia (NSH) and its related socio-demographic and clinical risk factors in a general population of Canadian adults with type 2 diabetes mellitus (T2DM) taking insulin and/or secretagogues.
Diabetes mellitus (DM) is one of the largest epidemics the world has faced. Given the morbidity and mortality burden of DM, it is important to identify modifiable factors that affect the natural course of the disease. To estimate the overall DM risk of fermented dairy foods intake, the present meta-analysis was carried out on published studies.
Semaglutide and liraglutide are GLP-1 based diabetes drugs, while semaglutide possesses even longer half-life. Utilizing relatively lower dosages, we compared metabolic beneficial effects of these two drugs in HFD-fed mice, aiming to deepen our mechanistic understanding on their energy homeostatic functions.
A low-carbohydrate high-fat ketogenic diet program implemented by an interdisciplinary primary care team improves markers of cardiometabolic health in adults with type 2 diabetes: A retrospective secondary analysis
Application of machine learning to assess interindividual variability in rapid-acting insulin responses following subcutaneous injection in people with type 1 diabetes.
Circulating insulin concentrations mediate vascular-inflammatory and prothrombotic factors. However, whether interindividual differences in circulating insulin levels are associated with different inflammatory and prothrombotic profiles in type 1 diabetes (T1D) is unknown. We applied an unsupervised, machine-learning approach to assess whether interindividual differences in rapid-acting insulin levels associate with parameters of vascular health in T1D patients.
Temporary Alternative Screening Strategy for Gestational Diabetes Screening During the COVID-19 Pandemic – The need for a middle ground
Diabetes mellitus is one of the most common pediatric chronic illnesses – while a rising incidence of childhood type 1 diabetes (T1D) has frequently been documented, an almost 400-fold variation in incidence has been seen worldwide. We aimed to describe the trends in incidence rates of diabetes (type 1, type 2, all types) among children and adolescents living in the Greater Montreal Area of Quebec, Canada.
“If we got a win-win, you can sell it to everybody”: A qualitative study employing Normalization Process Theory to identify critical factors for eHealth implementation and scale-up in primary care
Translation of eHealth research findings and successful implementation into clinical care is limited. We used a multi-tiered approach (individual, organizational, societal) to assess the implementation potential of MyDiabetesPlan within Ontario’s primary care system and applied the Normalization Process Theory (NPT) to explicate our findings.
Income inequalities and risk of early rehospitalization for diabetes, hypertension, and heart failure in the Canadian working age population
In the Canadian context of universal healthcare coverage, income inequalities are understudied as potentially predictive of the timings and patterns of repeat hospitalizations for diabetes, despite this condition requiring self-care practices entailing appreciable out-of-pocket expenses in daily life. This study examined the relationships between income disparities and risk of earlier readmission for diabetes and commonly comorbid chronic conditions in the working-age population.
Persons with diabetes and general/family practitioner perspectives related to therapeutic inertia in type 2 diabetes mellitus using qualitative focus groups and the Theoretical Domains Framework: Results from the MOTION study
Therapeutic inertia in type 2 diabetes (T2DM) is the failure to receive timely treatment intensification as indicated per T2DM treatment guidelines. Multifactorial causes of therapeutic inertia in T2DM have been documented at the level of persons with diabetes (PwD), healthcare providers, and healthcare systems.We developed a 3-part mixed-methods research program called the “Moving to Overcome Therapeutic Inertia Obstacles Now in T2DM” (MOTION) Study to inform the development of strategies to address therapeutic inertia in T2DM.
Patterns of nerve fiber impairments and neuronal activation in male diabetic rats with and without mechanical allodynia: a comparative study
It is still clinically difficult to definitively distinguish between painful and nonpainful diabetic peripheral neuropathy (DPN). In this study, pain patterns were further categorized; diabetic rats were grouped according to the presence or absence of mechanical allodynia (MA), which is a hallmark of neuropathic pain; and comparisons were made between diabetic rats with and without MA.
Economic analysis of a diabetes health coaching intervention for adults living with type 2 diabetes. A single centre evaluation from a community-based randomized controlled trial.
A community-based, telephone-delivered diabetes health coaching intervention is cost-effective.
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