Canadian Journal of Diabetes

Cardiovascular comorbidity associated with albuminuria in youth onset type 2 diabetes: analyses from the iCARE study


6 days 17 hours ago

Little is known about the relationship between albuminuria in youth with type 2 diabetes (T2D) and cardiovascular risk. We aimed to determine if youth with T2D and albuminuria have evidence of increased cardiovascular risk and/or earlycardiovascular dysfunction compared to youth with T2D without albuminuria.
Elizabeth A.C. Sellers, Allison B. Dart, Jonathan McGavock, Brandy A. Wicklow

A multi-intervention campaign lowers pediatric and young adult diabetic ketoacidosis hospitalizations in a Canadian province


1 week ago

The Newfoundland and Labrador Diabetic Ketoacidosis Project (NLdkaP) is a multi-intervention, province-wide project aimed at lowering rates of diabetic ketoacidosis (DKA) within the pediatric and young adult populations.
Georgia Darmonkow, Roger Chafe, Rana Aslanova, Donna Hagerty, Laurie Twells, Ola Jill Barter, Leigh Anne Allwood Newhook

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data


2 weeks 2 days ago

Type 1 diabetes is characterized by the autoimmune destruction of insulin secreting β cells. Genetic variations upstream at the insulin (INS) locus contribute to ∼10% of type 1 diabetes heritable risk. Multiple studies showed an association between rs3842753 C/C genotype and type 1 diabetes susceptibility, but the molecular mechanisms remain unclear. To date, no large-scale studies have looked at the effect of genetic variation at rs3842753 on INS mRNA at the single cell level. We aligned all human islet single cell RNA sequencing datasets available to us in 2020 to the reference genome GRCh38.98 and genotyped rs3842753, integrating 2315 β cells and 1223 beta-like cells from 13 A/A protected donors, 23 A/C heterozygous donors, and 35 C/C at-risk donors, including adults without diabetes and with type 2 diabetes.
Su Wang, Stephane Flibotte, Joan Camunas-Soler, Patrick E. MacDonald, James D. Johnson

Equity in Health Services Research—Finding Our Way Back


2 weeks 4 days ago

Over the past decade, many Health Services Research (HSR) studies have been guided by the Triple Aim Framework, which was introduced by the Institute for Healthcare Improvement (www.ihi.org) in 2007, and includes 3 dimensions: “improving the individual experience of care; improving the health of populations; and reducing the per capita costs of care” (1). The Triple Aim has proven a useful framework for quality improvement and health systems research. This issue of the Canadian Journal of Diabetes features several articles that relate to one or more of the 3 aims: changing Alberta’s insulin pump therapy eligibility criteria to improve selection and safety of individuals living with diabetes (2); using sensor-based technology to improve glycemia in individuals with type 1 diabetes (3); switching primary care providers from fee-for-service to capitation-based remuneration to improve diabetes care (4); and combining SGLT2 inhibitors with GLP-1 receptor agonists to improve cardiorenal outcomes (5), among others.
David J.T. Campbell

Adequacy between Canadian clinical guidelines and recommendations compared with international guidelines for the management of diabetic foot ulcers


3 weeks 4 days ago

Even though quality of care in the prevention and management of diabetic foot ulceration (DFU) is improved with the use of comprehensive evidence-based clinical practice guidelines, disparities between national and international guidelines have been demonstrated in one previous study conducted in Western Pacific regions. Although there are challenges of systematic implementation of evidence-base cares in some clinical settings, their applications have demonstrated positive outcomes on DFU associated burdens in many countries.
Virginie Blanchette, Jérôme Patry, Magali Brousseau-Foley

GLYCATED HEMOGLOBIN AS A FIRST LINE SCREENING TEST FOR CYSTIC FIBROSIS-RELATED DIABETES AND IMPAIRED GLUCOSE TOLERANCE IN CHILDREN WITH CYSTIC FIBROSIS: A VALIDATION STUDY


3 weeks 4 days ago

Study objectives were to document the screening rate for cystic fibrosis-related diabetes (CFRD) in children followed at a cystic fibrosis (CF) clinic in Canada and evaluate the accuracy of various glycated hemoglobin (A1C) cut-offs to screen for CFRD and impaired glucose tolerance (IGT) in a pediatric CF population.
Florence Racine, Azadeh Shohoudi, Valérie Boudreau, Cécile Nguyen, Marie-Hélène Denis, Katherine Desjardins, Quitterie Reynaud, Rémi Rabasa-Lhoret, Geneviève Mailhot

Insulin Therapy: The Discovery that Shaped a Century


3 weeks 5 days ago

The events and people surrounding the discovery of insulin as an effective therapy for diabetes in 1921 represent a compelling story that is directly relevant to the lives, and indeed the existence of tens of millions of people worldwide. This story begins in the 19th century with the recognition that diabetes is a disease of hyperglycemia that arises because of the absence of a pancreatic hormone, that rapidly leads to death in people classified as having “thin diabetes”, and that is linked to serious end-organ damage and other health consequences in people identified as having “fat diabetes”.
Hertzel C. Gerstein, Christopher J. Rutty

Use of virtual care for glycemic management in people with diabetes: a rapid review


1 month 2 weeks ago

The objective was to answer the main research question: In patients with diabetes, does virtual care vs. face to face care provide different clinical, patient and practitioner experience or quality outcomes? Articles (2012-2020) describing interventions using virtual care with capability for 2-way, individualized interactions compared with usual care were included. Studies involving any patients with diabetes and outcomes of A1C, quality of care and/or patient or HCP experience were included. Systematic reviews, randomized controlled, quasi-experimental, implementation trials, observational studies and qualitative analyses were reviewed.
Catherine B. Chan, Naomi Popeski, Mortaza Fatehi Hassanabad, Ronald J. Sigal, Petra O’Connell, Peter Sargious

Social Determinants of Health, Goals and Outcomes in High-Risk Children With Type 1 Diabetes


1 month 2 weeks ago

Despite advances in technology and type 1 diabetes (T1D) care, children from low-income families continue to have suboptimal outcomes and increased health-care utilization. In this study, we describe social determinants of health (SDOH) in high-risk children with T1D, as well as their SDOH-related priority goals, and assess the correlation between SDOH, glycemic control and health-care utilization.
Jennifer A. Hershey, Jennifer Morone, Terri H. Lipman, Colin P. Hawkes

Real World Patient Experience of Long-Term Hybrid Closed-Loop Insulin Pump Use


1 month 2 weeks ago

Understanding of patient experiences and adaptations to hybrid closed-loop (HCL) pumps beyond the confines of short-term clinical trials is needed to inform best practices surrounding this emerging technology. We investigated long-term, real-world patient experiences with HCL technology.
Linda R. Wang, Janine Malcolm, Amel Arnaout, Susan Humphrey-Murto, Kori A. LaDonna

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