Canadian Journal of Diabetes

Systematic Review and Meta-Analysis of Blood glucose Response to High Intensity Interval Exercise in Adults with Type 1 Diabetes


2 days 7 hours ago

Exercise-induced hyperglycemia is recognized in type 1 diabetes (T1D) clinical guidelines, but its association with high intensity intermittent exercise (HIIE) in acute studies is inconsistent. This meta-analysis examined the available evidence of blood glucose responses to HIIE in adults with T1D. The secondary aim was to examine predictors of blood glucose responses to HIIE. We hypothesized that there would be no consistent effect on blood glucose from HIIE, unless examined in the context of participant prandial status.
Reid D. McClure, Francisco Javier Alcántara-Cordero, Emma Weseen, Miranda Maldaner, Sarah Hart, Corbin Nitz, Normand G. Boulé, Jane E. Yardley

Care Coordination of Older Adults with Diabetes: A Scoping Review


1 week 2 days ago

Care coordination is a common intervention to support older adults with diabetes and their caregivers, and provides individualized, integrated health and social care. However, the optimal approach of care coordination is not well described. This scoping review synthesized evidence regarding the implementation of traditional and virtual care coordination for older adults with diabetes to inform future research and best practices.
Melissa Northwood, Aimun Qadeer Shah, Charith Abeygunawardena, Anna Garnett, Connie Schumacher

Effect of combined exercise training on physical and cognitive function in women with type 2 diabetes


1 week 2 days ago

One of the consequences of old age is cognitive and physical decline that can cause a wide range of problems in the elderly, and are more pronounced in those with type 2 diabetes (T2D). The aim of this pilot study was to investigate the effect of combined exercise training on blood biomarkers, physical fitness, and cognitive function in elderly women with T2D.
Nafiseh Ghodrati, Amir Hossein Haghighi, Seyed Alireza Hosseini Kakhak, Sadegh Abbasian, Gary S. Goldfield

Remission of Type 2 Diabetes


2 weeks 1 day ago

Diabetes Canada Clinical Practice Guidelines Expert Working Group, Dylan Mackay, Catherine Chan, Kaberi Dasgupta, Cliff Dominy, Michel Gagner, Susie Jin, James Kim, Jonathan Little, Barbara MacDonald, Natalia McInnes, Sonja Reichert, Harpreet S. Bajaj,…

Recent Developments in Islet Biology: A Review with Patient Perspectives


2 weeks 5 days ago

Navigating the coronavirus disease 2019 (COVID-19, now COVID) pandemic has required resilience and creativity worldwide. Despite early challenges to productivity, more than 2000 peer-reviewed articles in islet biology were published in 2021. Herein, we highlight noteworthy advances in islet research between January 2021- and April 2022, focusing on five areas. First, we discuss new insights into the role of glucokinase, MEK/ERK, and mitochondrial function on insulin secretion from the pancreatic β cell, provided by new genetically modified mouse models and live imaging.
Lahari Basu, Vriti Bhagat, Ma. Enrica Angela Ching, Anna Di Giandomenico, Sylvie Dostie, Dana Greenberg, Marley Greenberg, Jiwon Hahm, Zoe Hilton, Krista Lamb, Emelien M. Jentz, Matt Larsen, Cassandra A.A. Locatelli, MaryAnn Maloney, Christine MacGibbon,…

Metabolic Improvements and Remission of Prediabetes and Type 2 Diabetes: Results From a Multidomain Lifestyle Intervention Clinic


3 weeks 2 days ago

Although lifestyle interventions are first-line treatment for individuals living with prediabetes and type 2 diabetes (T2D), they are rarely implemented effectively in routine clinical care.
Josep Iglesies-Grau, Valérie Dionne, Louis Bherer, Nadia Bouabdallaoui, Lise Aubut, Florent Besnier, Johanne Bertholet, Annie Berthiaume, Marc Bisaillon, Mathieu Gayda, Christine Gagnon, Nacima Hamrioui, Élise Latour, Philippe L. L’Allier, Morissette C…

Provincial Care Gaps in Frequency of Hemoglobin A1C Testing in Alberta


3 weeks 4 days ago

Regular assessment of glycated hemoglobin (A1C) is a cornerstone to diabetes management. There are concerns on whether there is regular assessment of A1C and if clinical targets are being achieved. We sought to explore the frequency of A1C testing in Alberta and the factors associated with testing and glucose control.
Apisha Sri, Chuan Wen, Hude Quan, Amy Metcalfe, Kara Nerenberg, Peter Faris, Sonia Butalia

Rural Residence is Associated With a Delayed Trend Away From Sulfonylurea Use for Treatment Intensification of Type 2 Diabetes


3 weeks 4 days ago

Where a person resides may impact the health care they receive. Using a process-based approach, we examined the interplay between location of residence along the rural-urban continuum (metropolitan/urban/rural) and sulfonylurea (SU) dispensation records for the management of type 2 diabetes. This retrospective cohort study used administrative health records of adult new metformin users between April 2008–March 2019 in Alberta. Multivariate logistic regression was performed to examine the association between SU-based treatment intensification and location of residence.
Danielle Nagy, Lauren Bresee, Dean Eurich, Scot Simpson

Inequities in Recurrent Admissions of Diabetic Ketoacidosis: Cause for Concern


3 weeks 4 days ago

Diabetic ketoacidosis (DKA) is an acute and potentially fatal metabolic complication of type 1 diabetes and end-stage type 2 diabetes. Although largely preventable, it associates with morbidity and mortality, creating a large burden on the health system, particularly with recurrent presentations. This study reviewed 20 years of DKA admissions at a large regional hospital in New Zealand that serves a population of ∼500,000. Admissions for DKA were defined as new (diabetes diagnosis at admission), non-recurrent or recurrent (2 or more admissions), and they were analyzed by age group, ethnicity (indigenous Māori vs non-Māori), rurality and socioeconomic deprivation quintile.
Lynne Chepulis, Valentina Papa, Chunhuan Lao, Ryan Paul

Reduction in 1-Year Mortality After a Primary Lower Extremity Amputation Associated With Diabetes or Peripheral Artery Disease: What About the Severity of the Amputation?


3 weeks 4 days ago

Lower extremity amputations (LEA) associated with diabetes or peripheral arterial disease (PAD) result in important proportions of postoperative mortality. Given the lack of recent data in Quebec and the evolution of LEA trends in other Canadian provinces, we sought to document trends of 1-year mortality after primary LEA in Quebec from fiscal years 2006 to 2019.
Sarah O'connor, Claudia Blais, Jacinthe Leclerc, Jeremie Sylvain-Morneau, Elhadji Anassour Laouan Sidi, Denis Hamel, Paul Poirier

Evaluating Health Disparities in a Pediatric Population With Type 1 Diabetes


3 weeks 4 days ago

We sought to determine the association between SES and glycemic control in children with type 1 diabetes (T1D) followed at the Montreal Children’s Hospital (MCH), and whether insulin pump use, processes of care and depression modified the association. Using MCH’s Pediatric Diabetes Database, we conducted a retrospective cohort study of children ages 0 to 18 years diagnosed with T1D for at least a year with a visit between November 2019 and October 2020. Our outcome was mean glycated hemoglobin (HbA1c) in the following year.
Suzanne Simba, Elham Rahme, Julia Von Oettingen, Meranda Nakhla, Patricia Li

Addressing Diabetes Burden With Personalized Lifestyle and Habit Change Coaching


3 weeks 4 days ago

This study evaluated the impact of a personalized lifestyle and habit change program. Coaching was delivered virtually to participants in Newfoundland and Labrador (NL), where an estimated 34% of residents are living with type 1 or type 2 diabetes or are at risk of developing diabetes.
Alissa Setliff, Fraser Fry, Ashley Ryan, Lara Dodo, Natasha Vani, Hetal Oza-Sturgeon, Rohit Parab, Leonard Fensterheim

Technology-Enabled Collaborative Care for Diabetes (TECC-D): Feasibility and Acceptability of a Disruptive Integrated Care Model


3 weeks 4 days ago

Currently, individuals living with type 2 diabetes (T2D) and mental health issues navigate a fragmented health-care system to seek physical and mental health services. To address these gaps, we co-re-designed a person-centred Technology-Enabled Collaborative Care for Diabetes (TECC-D) model through iterative patient, provider and partner input.
Carly Whitmore, Diana Sherifali

Impact of Hybrid Care on Care Delivery and Obstetrical Outcomes on Women With Gestational Diabetes


3 weeks 4 days ago

Gestational diabetes mellitus (GDM) is a common disorder in pregnancy associated with maternal and fetal complications. The COVID-19 pandemic shifted care delivery from in-person to a hybrid model including in-person, phone and video encounters. This study compared clinic processes and obstetrical outcomes pre- and post-COVID.
Xing Sun, Alan Karovitch, Janine Malcolm, Tammy Shaw, Paloma O'meara, Erin Keely

Improving Equality in Outcomes for Indigenous Peoples With Type 2 Diabetes: Use of Special Authority Criteria


3 weeks 4 days ago

Type 2 diabetes (T2D) and its burden of cardiovascular (CV) and renal complications disproportionately affect Indigenous Māori in Aotearoa, New Zealand. This suggests that increased prescribing (over and above non-Māori) is required in these groups to ensure equality of outcomes. Although widely available overseas, New Zealand has only recently (February 2021) approved empagliflozin (a sodium-glucose cotransporter-2 inhibitor [SGLT2i]) and dulaglutide (a glucagon-like peptide-1 receptor agonist [GLP1RA]) for use in T2D.
Lynne Chepulis, Mark Rodrigues, Jo Scott-Jones, Alex Poor, Ryan Paul

Essential Diabetes Medicines and Health Outcomes in 127 Countries


3 weeks 4 days ago

Improving access to diabetes medicines may decrease mortality. Diabetes medicines on national essential medicines lists (NEMLs) vary considerably. We examine the association between diabetes population health outcomes relating to mortality and the listing of diabetes medicines on NEMLs for 127 countries.
Dalton Budhram, Simran Benipal, Krish Bilimoria, Darshanand Maraj, Ri Wang, Nav Persaud

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