Canadian Journal of Diabetes

Blood Glucose Monitoring in Adults and Children with Diabetes: Update 2021


2 weeks 3 days ago

The Diabetes Canada Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada (CPG) were last published in 2018 (1). Rapid uptake of new monitoring technologies by persons living with diabetes and uncertainty among health-care professionals prompted a review of evidence emerging since our previous recommendations for “Monitoring Glycemic Control” (2). We have updated the title for this topic to align with Diabetes Canada’s position statement on “Language Matters” (3).
Diabetes Canada Clinical Practice Guidelines Expert Working Group, Alice Y.Y. Cheng, Denice S. Feig, Josephine Ho, Rick Siemens, Diabetes Canada Clinical Practice Guidelines Steering Committee

Does the presence of type 2 diabetes or metabolic syndrome impact reduction in waist circumference during weight loss?


3 weeks 2 days ago

To compare the change in waist circumference given the same degree of weight loss in patients who meet the criteria for metabolic syndrome or type 2 diabetes and those who do not. Since visceral adiposity, is a key feature of both conditions, we hypothesized that patients with metabolic syndrome or diabetes lose a greater amount of waist circumference given the same amount of weight loss compared to patients without these conditions.
Xu Chi, Barbara Bielawska, Majid Nikpay, Robert Dent

Approaches to psychosocial care within tertiary care diabetes centres in Canada: An environmental scan.


3 weeks 3 days ago

Patients with diabetes facing psychosocial challenges often struggle with diabetes self-management, and thereby are at risk of complications arising from hyperglycemia. Despite the Diabetes Canada Clinical Practice Guidelines’ recommendations for diabetes centres to offer psychosocial services for the screening and support of patients with psychosocial barriers, the extent to which these recommendations have been implemented in centres across Canada is unknown.
Simarprit Sidhu, Pablo M. Gonzalez, Danielle Petricone-Westwood, Clive S. Brewis, Doreen M. Rabi, David J.T. Campbell

Real-world incidence and risk factors for daytime and nocturnal non-severe hypoglycemia in adults with type 2 diabetes mellitus on insulin and/or secretagogues (InHypo-DM Study, Canada)


4 weeks ago

To estimate the real-world incidence of self-reported non-severe hypoglycemia (NSH) and its related socio-demographic and clinical risk factors in a general population of Canadian adults with type 2 diabetes mellitus (T2DM) taking insulin and/or secretagogues.
Natalie H. Au, Alexandria Ratzki-Leewing, Guangyong Zou, Bridget L. Ryan, Susan Webster-Bogaert, Sonja M. Reichert, Judith B. Brown, Stewart B. Harris

Fermented dairy foods intake on the risk of diabetes mellitus: results from meta-analysis


1 month ago

Diabetes mellitus (DM) is one of the largest epidemics the world has faced. Given the morbidity and mortality burden of DM, it is important to identify modifiable factors that affect the natural course of the disease. To estimate the overall DM risk of fermented dairy foods intake, the present meta-analysis was carried out on published studies.
Kui Zhang, Peng Bai, Zhenhua Deng

Comparison of metabolic beneficial effects of Liraglutide and Semaglutide in male C57BL/6J mice


1 month 1 week ago

Semaglutide and liraglutide are GLP-1 based diabetes drugs, while semaglutide possesses even longer half-life. Utilizing relatively lower dosages, we compared metabolic beneficial effects of these two drugs in HFD-fed mice, aiming to deepen our mechanistic understanding on their energy homeostatic functions.
Dinghui Liu, Jianqiu Gu, Weijuan Shao, Juan Pang, Xiaoxian Qian, Tianru Jin

Application of machine learning to assess interindividual variability in rapid-acting insulin responses following subcutaneous injection in people with type 1 diabetes.


1 month 1 week ago

Circulating insulin concentrations mediate vascular-inflammatory and prothrombotic factors. However, whether interindividual differences in circulating insulin levels are associated with different inflammatory and prothrombotic profiles in type 1 diabetes (T1D) is unknown. We applied an unsupervised, machine-learning approach to assess whether interindividual differences in rapid-acting insulin levels associate with parameters of vascular health in T1D patients.
Eleanor M. Coales, Ramzi A. Ajjan, Sam M. Pearson, Lauren L. O’Mahoney, Noppadol Kietsiriroje, Jan Brož, Mel Holmes, Matthew D. Campbell

Increasing incidence of type 1 and 2 diabetes among Canadian children


1 month 4 weeks ago

Diabetes mellitus is one of the most common pediatric chronic illnesses – while a rising incidence of childhood type 1 diabetes (T1D) has frequently been documented, an almost 400-fold variation in incidence has been seen worldwide. We aimed to describe the trends in incidence rates of diabetes (type 1, type 2, all types) among children and adolescents living in the Greater Montreal Area of Quebec, Canada.
Alexandra Cohen, Elise Mok, Marc Simard, Marjolaine Dubé, Isabelle Larocque, Celine Plante, Laurent Legault, Céline Huot, Sarah Wafa, Elham Rahme, Meranda Nakhla

“If we got a win-win, you can sell it to everybody”: A qualitative study employing Normalization Process Theory to identify critical factors for eHealth implementation and scale-up in primary care


1 month 4 weeks ago

Translation of eHealth research findings and successful implementation into clinical care is limited. We used a multi-tiered approach (individual, organizational, societal) to assess the implementation potential of MyDiabetesPlan within Ontario’s primary care system and applied the Normalization Process Theory (NPT) to explicate our findings.
Arani Sivakumar, Rachel Y. Pan, Dorothy Choi, Angel He Wang, Catherine H. Yu

Income inequalities and risk of early rehospitalization for diabetes, hypertension, and heart failure in the Canadian working age population


1 month 4 weeks ago

In the Canadian context of universal healthcare coverage, income inequalities are understudied as potentially predictive of the timings and patterns of repeat hospitalizations for diabetes, despite this condition requiring self-care practices entailing appreciable out-of-pocket expenses in daily life. This study examined the relationships between income disparities and risk of earlier readmission for diabetes and commonly comorbid chronic conditions in the working-age population.
Eric Comeau, Phil Leonard, Neeru Gupta

Persons with diabetes and general/family practitioner perspectives related to therapeutic inertia in type 2 diabetes mellitus using qualitative focus groups and the Theoretical Domains Framework: Results from the MOTION study


1 month 4 weeks ago

Therapeutic inertia in type 2 diabetes (T2DM) is the failure to receive timely treatment intensification as indicated per T2DM treatment guidelines. Multifactorial causes of therapeutic inertia in T2DM have been documented at the level of persons with diabetes (PwD), healthcare providers, and healthcare systems.We developed a 3-part mixed-methods research program called the “Moving to Overcome Therapeutic Inertia Obstacles Now in T2DM” (MOTION) Study to inform the development of strategies to address therapeutic inertia in T2DM.
Paulina K. Wrzal, Amir A. Mohseni, Carl Fournier, Ronald Goldenberg, Debbie Hollahan, Susie Jin, Sue D. Pedersen, Michael Vallis, Andrean Bunko, Varun Myageri, Atif Kukaswadia, Calum S. Neish, Noah M. Ivers

Patterns of nerve fiber impairments and neuronal activation in male diabetic rats with and without mechanical allodynia: a comparative study


2 months ago

It is still clinically difficult to definitively distinguish between painful and nonpainful diabetic peripheral neuropathy (DPN). In this study, pain patterns were further categorized; diabetic rats were grouped according to the presence or absence of mechanical allodynia (MA), which is a hallmark of neuropathic pain; and comparisons were made between diabetic rats with and without MA.
Chenlong Liao, Han Zhou, Hongjin Chen, Xiaosheng Yang, Wenxiang Zhong, Wenchuan Zhang

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