Canadian Journal of Diabetes

Comparison of the efficacy and safety of commercially available fixed ratio combinations of insulin degludec/liraglutide (IDegLira) and insulin glargine/lixisenatide (iGlarLixi) – a network meta-analysis

4 days 4 hours ago

To compare the efficacy and safety of commercially available fixed ratio combinations (FRC) of glucagon-like peptide 1 receptor agonists (GLP-1RA) and basal insulins by a network meta-analysis (NMA) of randomised controlled trials (RCT) of type 2 diabetes patients.
Gergely Á. Visolyi, Beatrix A. Domján, Márk M. Svébis, Anna Péterfi, Barbara D. Lovász, Szilvia Mészáros, Viktor J. Horváth, Ádám G. Tabák

Impact of the COVID-19 Pandemic on Antihyperglycemic Prescriptions for Adults with Type 2 Diabetes in Canada: A Cross-Sectional Study

5 days 4 hours ago

Diabetes is a major public health problem in Canada and requires multifactorial, consistent clinical management. The COVID-19 pandemic increased challenges in the management of many chronic ailments, including diabetes. Diabetes was associated with a higher risk of severe illness in the context of COVID-19. Pandemic restrictions also impacted diabetes care continuity, which may have contributed to an increased risk of diabetes-related complications and mortality.
Alice YY Cheng, Ronald Goldenberg, Iris Krawchenko, Richard Tytus, Jina Hahn, Aiden Liu, Shane Golden, Brad Millson, Stewart Harris

Low-calorie Diets for Remission of Type 2 Diabetes -- Do the Benefits Outweigh the Risks?

1 month ago

I am writing regarding the recently published Diabetes Canada Clinical Practice Guidelines special articles “Remission of Type 2 Diabetes” (1) and “Remission of type 2 diabetes: User’s guide” (2). I see these articles as an acknowledgment from the mainstream medical community that it is indeed possible to normalize blood sugars for an uncertain timespan after a diagnosis of type 2 diabetes. I also applaud the authors’ sincere efforts at recognizing the limitations of these approaches. I was heartened to read that the psychological impacts of weight stigma and “failure” to achieve remission were given significant attention in these articles.
Yun (Cathy) Wang

The association between diabetes and mortality among adult patients hospitalized with COVID-19: Cohort Study of Hospitalized Adults in Ontario, Canada and Copenhagen, Denmark

1 month ago

Diabetes has been reported to be associated with an increased risk of death among patients with COVID-19. However, available studies lack detail on COVID illness severity and measurement of relevant comorbidities.
Orly Bogler, Afsaneh Raissi, Michael Colacci, Andrea Beaman, Tor Biering-Sørensen, Alex Cressman, Allan Detsky, Alexi Gosset, Mats Højbjerg Lassen, Chris Kandel, Yaariv Khaykin, David Barbosa, Lauren Lapointe Shaw, Derek R. MacFadden, Alexander Pearson,…

Reducing Sitting Time in Type 1 Diabetes: Considerations and Implications

1 month 2 weeks ago

Sedentary behaviours are ubiquitous in modern society with Western populations spending approximately ∼50% of their waking hours in low levels of energy expenditure. This behaviour is associated with cardiometabolic derangements and increased morbidity and mortality. In individuals living with or at risk of developing type 2 diabetes (T2D), “breaking up” sedentariness, by interrupting prolonged periods of sitting has been shown to acutely improve glucose control and cardiometabolic risk factors related to diabetes complications.
Anwar M. Alobaid, Paddy C. Dempsey, Monique Francois, Michael A. Zulyniak, Mark Hopkins, Matthew D. Campbell

Canadian Cystic Fibrosis–related Diabetes Clinical Practice Survey: Analysis of Current Practices and Gaps in Clinical Care

1 month 2 weeks ago

Our aim in this study was to identify challenges and gaps in Canadian practices in screening, diagnosis and treatment of cystic fibrosis–related diabetes (CFRD), with the goal of informing a Canadian-specific guideline for CFRD.
Kathryn J. Potter, Adèle Coriati, Patrick Hicks, Larry C. Lands, Martha L. McKinney, Valérie Boudreau, Anne Bonhoure, Paola Luca, Josephine Ho, Sémah Tagougui, Amanda Jober, Meghan Pohl, Elizabeth T. Rosolowsky, Julie Gilmour, Grace Y. Lam, Anne L…

Recommended Weight Care for Patients Living With Type 1 Diabetes: A Consensus From The Charles H. Best Diabetes Centre

1 month 2 weeks ago

Obesity is a pressing burden in type 1 diabetes mellitus (T1DM) (1,2) and weight maintenance is a constant struggle in the lives of people living with T1DM. Although broad recommendations exist for improving lifestyle habits to manage weight in people living with diabetes (3–6), T1DM-specific patient-centred guidelines are lacking. With the goal of narrowing this care gap, a working group from The Charles H. Best Diabetes Centre (CHBC) was assembled to review the literature and consolidate 33 years of expertise to develop a standard approach for optimal weight-care provision that specifically considers the unique needs of individuals living with T1DM.
Jeremy D. Gilbert, Diana Balicsak, Susan Kettle, Valerie S. Lewis, Natalie Medel, Christopher W. Montgomery, Lorrie Hagen

Indigenous Peoples and Type 2 Diabetes: A Discussion of Colonial Wounds and Epistemic Racism

1 month 3 weeks ago

Racism is rooted in historic and ongoing colonial strategies designed to erase, silence and dismiss Indigenous peoples’ voices, personhood and worldview. Although within health care today interpersonal racism (discriminatory treatment) is commonly reported on, racism also influences our understanding of health conditions and related treatments. Epistemic racism, the discrimination of how we know, operates through the questions we ask to advance our evidence, and whose knowledge is sought and deemed valid.
Moneca Sinclaire, Barry Lavallee, Monica Cyr, Annette Schultz

Thyroid Dysfunction and Cardiovascular Events in Patients With Dysglycemia

1 month 3 weeks ago

Subclinical thyroid disease is the most common form of thyroid dysfunction and may be associated with adverse cardiovascular outcomes in people at high risk for cardiovascular events. Our objective in this study was to assess the association of thyroid function and thyroid hormone replacement with cardiovascular outcomes in high-risk individuals with dysglycemia and additional cardiovascular risk factors.
Reema Shah, Steven Orlov, Guillaume Paré, Hertzel C. Gerstein

Use of Classes of Antihyperglycemic Agents in People With Type 2 Diabetes Based on Level of Estimated Glomerular Filtration Rate

2 months ago

Diabetes is the leading cause of kidney disease in Canada, with up to one-half of people with diabetes experiencing symptoms of renal damage in their lifetime (1). Through stable and in-target glycemic management that has been individualized to optimize a person’s self-management and care, the development and progression of renal damage can be reduced (2).
Diabetes Canada Clinical Practice Guidelines Expert Working Group, Jeremy Gilbert, Phil McFarlane, James Kim, Susie Jin, Peter Senior, Diabetes Canada Clinical Practice Guidelines Dissemination & Implementation Committee and the Clinical Practice…

Exercise and Diabetes: A Moving Target?

2 months ago

Physical activity (PA) is essential to leading a healthy life with diabetes, but many individuals with diabetes find it challenging to be active on a regular basis. In general, people with diabetes are less active than their counterparts without diabetes (1). On top of the regular barriers to being active, such as lack of time, lack of infrastructure/resources, and lack of knowledge about exercise and its benefits, people with diabetes list additional barriers that include (but are not limited to) fear of hypoglycemia (in particular in those with type 1 diabetes) (2) and lower health-related quality of life (3).
Jane E. Yardley

Changes in Cognition and Brain Function After 26 Weeks of Progressive Resistance Training in Older Adults at Risk for Diabetes: A Pilot Randomized Controlled Trial

2 months 2 weeks ago

Type 2 diabetes is associated with deficits in cognition and brain health. Individuals with at least 1 risk factor for diabetes (i.e. obesity, prediabetes) already experience some neurocognitive impairment and are at risk for further decline. One way to combat these deficits is through exercise, but its is unknown whether resistance exercise can improve these functions in this at-risk group.
Joyla A. Furlano, Becky R. Horst, Robert J. Petrella, J. Kevin Shoemaker, Lindsay S. Nagamatsu

Impact of the COVID-19 Pandemic on Adults With Type 2 Diabetes Care and Clinical Parameters in a Primary Care Setting in Ontario, Canada: A Cross-sectional Study

2 months 2 weeks ago

Diabetes requires ongoing monitoring and care to prevent long-term adverse health outcomes. In Canada, quarantine restrictions were put into place to address the coronavirus-2019 (COVID-19) pandemic in March 2020. Primary care diabetes clinics limited their in-person services and were advised to manage type 2 diabetes (T2D) through virtual visits and reduce the frequency of routine diabetes-related lab tests and screening.
Alice Y.Y. Cheng, Stewart Harris, Iris Krawchenko, Richard Tytus, Jina Hahn, Aiden Liu, Brad Millson, Shane Golden, Ronald Goldenberg

2 hours 47 minutes ago
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