Canadian Journal of Diabetes

Diabetic retinopathy: important biochemical alterations and the main treatment strategies

5 days 20 hours ago

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by impaired glucose homeostasis, insulin resistance and hyperglycemia. Among its serious multi-systemic complications is diabetic retinopathy (DR), which develops slowly and often insidiously. This disorder, the most common cause of vision loss in working-age adults, is characterized by functional and morphological changes in the retina. It results from the exacerbation of ischemic and inflammatory conditions prompted by alterations in the blood vessels, such as the development of leukostasis, thickening of the basement membrane, retinal neovascularization and fibrovascular tissue formation at the vitreoretinal interface.
A.S. Valdez-Guerrero, J.C. Quintana-Pérez, M.G. Arellano-Mendoza, F.J. Castañeda-Ibarra, F. Tamay-Cach, D. Alemán-González-Duhart

Assessing the Quality of Evidence Presented at the Annual Conferences of Diabetes Canada

1 week 4 days ago

Annual general meetings (AGMs) are often seen and promoted as great sources of contemporary information for the modern healthcare professional. The quality of research evidence presented at these conferences, however, remains unclear. This paper evaluates the level of evidence (LoE) of research presented at the 2015 to 2019 AGMs of Diabetes Canada (DC).
Muhammad Shoker, Logan Hahn, Ameen Patel, Nasim Zamir

HbA1c and Blood Pressure Levels in Type 2 Diabetes: How Many Patients are on Target?

1 week 4 days ago

Achieving HbA1c and blood pressure targets is an important strategy for preventing chronic vascular complications in diabetes. The aim of this paper was to determine the proportion of type 2 diabetes patients who meet the recommended HbA1c and arterial blood pressure targets and the determinants of failure to do so.
C.B. Farias, S. Coelli, F. Satler, L. Brondani, T. Zelmanovitz, S.P. Silveiro

An Evaluation of Reach and Effectiveness of a Diabetes Prevention Behaviour Change Program Situated in a Community Site

1 week 4 days ago

More than 350 million people are living with prediabetes. Preventing type 2 diabetes (T2D) progression can reduce morbidity, mortality, and healthcare costs. Interventions can support people with diet and physical activity behaviour changes; however, many interventions are university-based, posing barriers (e.g., accessibility, limited reach, maintenance), which highligh the need for community intervention. Limited research has comprehensively evaluated programs in community contexts. The purpose of this study was to pragmatically examine the reach and effectiveness of a diabetes prevention behaviour change program in the community using the RE-AIM framework.
Corliss Bean, Tineke Dineen, Sean R. Locke, Brooklyn Bouvier, Mary E. Jung

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): An Emerging Complication of Pre-Gestational Diabetes Mellitus Among First Nations and Non-First Nations People in Saskatchewan Results from the DIP: ORRIIGENSS Project

1 week 6 days ago

Because congenital anomalies of the kidneys and urinary tract (CAKUT) are a frequent cause of end stage renal disease (ESRD) in the young, we explored the epidemiology of CAKUT and the role of diabetes in pregnancy.
Roland F. Dyck, Chandima Karunanayake, Punam Pahwa, MaryRose Stang, Robin L. Erickson, Nathaniel D. Osgood


3 weeks 1 day ago

Diabetic foot ulcer (DFU), an important complication of diabetes, is associated with increased morbidity and mortality, and generates a significant social and economic burden. However, DFU quality of care has been insufficiently studied. Therefore, the aim of this study was to evaluate the quality of DFU care of an interdisciplinary wound care clinic in Canada, based on an extended Donabedian model: structure, process and outcome quality indicators combined with patient characteristics.
Jérôme Patry, André Tourigny, Marie-Philippe Mercier, Clermont E. Dionne

Pharmacologic Glycemic Management of Type 2 Diabetes in Adults: 2020 Update

3 weeks 4 days ago

The Diabetes Canada Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada (CPG) were last published in 2018 (1). New evidence has been published since the 2018 guidelines, prompting this update to our recommendations for Chapter 13, “Pharmacologic Glycemic Management of Type 2 Diabetes in Adults” (1).
Diabetes Canada Clinical Practice Guidelines Expert Committee, Lorraine Lipscombe, Sonia Butalia, Kaberi Dasgupta, Dean T. Eurich, Lori MacCallum, Baiju R. Shah, Scot Simpson, Peter A. Senior

Pharmacologic Glycemic Management of Type 2 Diabetes in Adults: 2020 Update – The User’s Guide

3 weeks 4 days ago

Diabetes Canada prepares clinical practice guidelines to provide a synthesis of the best evidence to help practitioners. Evidence-based medicine seeks to integrate the best evidence with clinical expertise and the values of persons living with diabetes. It is challenging to balance the goals of providing guidelines based on high-quality evidence with addressing the needs of practitioners who commonly face clinical scenarios for which there is no robust evidence.
Diabetes Canada Clinical Practice Guidelines Steering Committee, Peter A. Senior, Robyn L. Houlden, James Kim, Dylan Mackay, Seema Nagpal, Doreen Rabi, Diana Sherifali, Harpreet S. Bajaj

Intergenerational Impacts of Colonization: Outcomes of Diabetes in Pregnancy for First Nations Families

3 weeks 4 days ago

Rates of youth- and early-onset type 2 diabetes (T2D) are on the rise in Canada, a disease that, until the early 1980s, was only seen in older adults. As a result, more women have T2D during pregnancy than ever. Currently, approximately 6% of pregnancies in Canada are complicated by maternal diabetes, which contributes significantly to greater rates of antenatal, perinatal and postnatal complications for both mother and child (1). To compound matters, mounting evidence demonstrates that exposure to diabetes in utero increases the likelihood that the offspring will develop T2D, and at a significantly younger age, creating a cycle of pregnancies complicated by diabetes and another generation having greater risk of T2D development.
Taylor S. Morriseau, Brandy A. Wicklow, Barry Lavallee

7 minutes 46 seconds ago
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